294177-74-5

Upstream product

• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 621-82-9 Cinnamic acid 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 102-92-1 cinnamoyl chloride 

Downstream Products

• 1632322-78-1 (S)-methyl 2-(3-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-3-phenylpropanamido)-3-phenylpropanoate 
• 1632322-77-0 methyl 2-(3-(4-ethyl-3,5-dimethyl-1H-pyrrol-2-yl)-3-phenylpropanamido)-3-phenylpropanoate 
• 4950-65-6 cinnamoyl-L-phenylalanine 

Relevant academic research and scientific papers

α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment

The main protease of coronaviruses and the 3C protease of enteroviruses share a similar active-site architecture and a unique requirement for glutamine in the P1 position of the substrate. Because of their unique specificity and essential role in viral po

Anti-enteroviral 71(EV71) 4-iminooxazolidine-2-ketone compound as well as preparation method and application of anti-enteroviral 71(EV71) 4-iminooxazolidine-2-ketone compound

The invention discloses a 4-iminooxazolidine-2-ketone enterovirus 71(EV71) 3C protease inhibitor of which the structural general formula is shown as a compound (M), each variable in the structure is defined as the specification, and the compounds are used for effectively inhibiting or stopping the replication of enterovirus 71. The invention relates to discovery and application of a compound with a structure shown as the formula (M) as well as various optical isomers of the compound, a pharmaceutically active metabolite, a medicinal salt, a solvate and a prodrug of the compound in preparation of antiviral drugs for treating hand-foot-mouth virus infection diseases and also relates to an intermediate for preparing the compound with the structure shown as the formula (M) and a synthesis method.

Studies of the new reactivity of chiral acrylamides and unprotected pyrroles: Diastereoselective and carbonyl compatible 1,4-addition

A diversity of new functionalized cyclic and acyclic chiral pyrroloamides compounds were synthesized in good yields and diastereoselectivities in the case of cyclic pyrroloamides. This simple and robust process involves the creation of a C-C bond between unprotected pyrroles and cyclic or hindered chiral acrylamides. Georg Thieme Verlag Stuttgart New York.

Antimicrobial activities of the cinnamoyl amide of amino acid derivatives

Cinnamic acid derivatives are well known natural antimicrobial compounds. In present studies, 23 cinnamoyl amides of amino acid derivatives were synthesized and their antimicrobial activities against Bacillus subtilis, Escherichia coli and Saccharomyces cerevisiae were evaluated with benzoic acid as a reference. Most of the synthesized compounds were more active in inhibiting bacterial growth and all of them were more sensitive in controlling the growth of yeast Saccharomyces cerevisiae than cinnamic acid. Moreover, some of them such as cinnamoyl butyl glycinate(compound 4) were more active than benzoic acid. The pH value influence on the antimicrobial activities of compound 4 was also investigated. Compared to benzoic acid, compound 4 was much more active when pH value was up to 7 and 7.5. These results gives us useful information for food preservatives.