294182-30-2Relevant academic research and scientific papers
New antifungal 1,2,4-triazoles with difluoro(heteroaryl)methyl moiety
Eto, Hiromichi,Kaneko, Yasushi,Sakamoto, Takao
, p. 982 - 990 (2007/10/03)
New 1,2,4-triazoles (1) having a difluoro(heteroaryl)methyl moiety were designed and synthesized via 1-aryl-2,2-difluoro-2- (heteroaryl)ethanones (2), which were prepared by two routes starting from the reaction of ethyl 2,2- difluoro(heteroaryl)acetate with phenyllithiums (Route A) and from the reaction of chlorodifluoro(heteroaryl)methane with benzaldehydes (Route B). The compounds 1 except for 1g show antifungal activities against yeasts and filamentous fungi in vitro, especially (+)-If have equal or superior activities compared to those of itraconazole.
