294193-56-9Relevant academic research and scientific papers
Synthesis of novel 3-(4-acetyl-5H/methyl-5-substituted phenyl-4,5-dihydro- 1,3,4-oxadiazol-2-yl)-2H-chromen-2-ones as potential anticonvulsant agents
Bhat, Mashooq A.,Siddiqui, Nadeem,Khan, Suroor A.
experimental part, p. 235 - 239 (2009/04/04)
A series of 3-(4-acetyl-5H/methyl-5-substituted phenyl-4,5-dihydro-1,3,4- oxadiazol-2-yl)-2H-chromene-2-ones (6a-j) were synthesized and evaluated for anticonvulsant activity and neurotoxicity. The structures of the synthesized compounds were confirmed on the basis of their spectral data and elemental analysis. A majority of the compounds was active in MES tests. Compound (6e) was found to be potent and had activity at lower dose of 30 mg/kg in MES-test. All the compounds were less toxic as compared with the standard drug phenytoin.
