294198-94-0Relevant academic research and scientific papers
Samarium diiodide promoted reduction of 3,6-dihydro-2H-1,2-oxazines: Competition of 1,4-amino alcohol formation and ring contraction to pyrrole derivatives
Jasinski, Marcin,Watanabe, Toshiko,Reissig, Hans-Ulrich
, p. 605 - 610 (2013/02/26)
An approach to enantiopure 1,4-amino alcohols of type 4 by samarium diiodide mediated N-O cleavage of 3,6-dihydro-2H-1,2-oxazines 3 is presented. In several cases we observed the formation of 3-methoxypyrrole derivatives 5 as byproducts in significant amo
A stereodivergent synthesis of enantiopure 3-methoxypyrrolidines and 3- methoxy-2,5-dihydropyrroles from 3,6-dihydro-2H-1,2-oxazines
Pulz, Robert,Watanabe, Toshiko,Schade, Wolfgang,Reissig, Hans-Ulrich
, p. 983 - 986 (2007/10/03)
Hydrogenolysis of syn-3,4-dihydro-2H-1,2-oxazine (syn-2) in the presence of palladium on charcoal provided a diastereomeric mixture of amino alcohols 3a/3b from which pyrrolidine derivative 4a was obtained as major isomer after cyclization. Reduction with
