294204-23-2

Upstream product

• 452-63-1 2-Bromo-5-fluorotoluene 
• 294204-21-0 1-bromo-4-fluoro-2-methyl-5-(methylsulfonyl)benzene 
• 16706-54-0 N-Cbz-guanidine 
• 294204-22-1 2-methyl-5-methylsulfonyl-4-(pyrrol-1-yl)benzoic acid 
• 190367-38-5 4-fluoro-2-methyl-5-(methylsulfonyl)benzoic acid 

Relevant academic research and scientific papers

A concise and efficient synthesis of [2-methyl-5-methylsulfonyl-4- (pyrrol-1-yl)benzoyl]guanidinium methanesulfonate (Eniporide)

A new synthesis of the benzoylguanidine-type Na+/H+ antiporter inhibitor eniporide (7) is described. Starting from 2-bromo-5-fluorotoluene (1), aromatic substituents were introduced by methanesulfonylation, Pd- catalyzed carboxylation with CO, and halogen-pyrrole exchange. Guanidine acylation was performed using Mukaiyama's procedure.