29421-75-8

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
4-Bromo-5-methyl-2-thiophenecarbaldehyde is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals for its ability to contribute to the development of new drugs and pesticides, enhancing their efficacy and properties.
Used in Dye and Pigment Production:
In the dye and pigment industry, 4-Bromo-5-methyl-2-thiophenecarbaldehyde is utilized as a key component in the production of various dyes and pigments, contributing to their color and stability.
Used as a Building Block in Organic Chemistry:
4-Bromo-5-methyl-2-thiophenecarbaldehyde is used as a versatile building block in organic chemistry for its capacity to serve as a precursor to a wide array of derivatives, enabling the creation of compounds with different functional groups and applications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 4-Bromo-5-methyl-2-thiophenecarbaldehyde is used for its potential biological activity, particularly as an antimicrobial or antifungal agent, offering new avenues for the development of treatments against infectious diseases.

Upstream product

• 13679-70-4 5-methylthiophene-2-carboxaldehyde 
• 29421-73-6 3,5-dibromo-2-methylthiophene 
• 68-12-2 N,N-dimethyl-formamide 
• 554-14-3 2-Methylthiophene 

Downstream Products

• 882506-11-8 (4-bromo-5-methylthiophen-2-yl)methanol 
• 154566-75-3 1,2-bis(5'-formyl-2'-methylthien-3'-yl)perfluorocyclopentene 
• 1315330-93-8 3-(4-bromo-5-methyl-thien-2-yl)-2-cyanoacrylic acid 
• 1315330-95-0 3-[4-(4-aminophenyl)-5-methyl-thien-2-yl]-2-cyanoacrylic acid 
• 1315330-98-3 N-(2,6-diisopropylphenyl)-N'-{4-[2-methyl-5-(cyanoacrylic acid)-3-thienyl]-phenyl}-1,7-bis(6-undecanoxy)perylene-3,4,9,10-tetracarboxylic diimide 
• 1437786-93-0 1-(4-bromo-5-methylthiophen-2-yl)-N-(4-chlorobenzyl)-N-(pyridin-3-ylmethyl)methanamine 
• 1195623-96-1 5-methyl-4-bromo-2-thiopheneformaldehyde diethyl acetal 

Relevant academic research and scientific papers

Gating charge recombination rates through dynamic bridges in tetrathiafulvalene-fullerene architectures

An open and shut case: The competition between charge separation and recombination in artificial photosynthetic systems can be controlled by using photochromic dynamic bridge. The photoinduced opening and closing of the bridge mediates the electronic coupling between donor (D) and acceptor (A). Copyright

Absolute stereochemistry and CD spectra of resolved enantiomers of the colored form of a photochromic dithienylethene

The colored form of photochromic 1,2-bis(5-hydroxymethyl-2-methyl-3-thienyl)hexafluorocyclopentene was resolved into enantiomers by HPLC. The absolute stereochemistry of an enantiomer was determined on its bis(4-chlorobenzoate). The CD spectra and optical rotation of the resolved colored form were measured.

NOVEL COMPOUNDS HAVING INHIBITORY ACTIVITY ON PROSTAGLANDIN E2 RECEPTOR AND USES THEREOF

The present application relates to a novel compound having inhibitory activity on prostaglandin E2 receptor and uses thereof, and provides a compound represented by formula I, a solvate, stereoisomer or pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the same, and a method of using the same.

Stabilization of ultra-small gold nanoparticles in a photochromic organic cage: modulating photocatalytic CO2reduction by tuning light irradiation

Synthesis and stabilization of ultra-small metal nanoparticles (MNPs) composed of a few atoms are of paramount importance in modulating their material properties based on quantum confinement effects. The highly reactive surface of small MNPs tends to aggregate, resulting in bigger particles and subsequent deterioration of the catalytic activity. In this work, we exploited a dithienylethene (DTE) based photochromic organic cage (TAE-DTE) for thein situstabilization of ultra-small Au NPs (Au@TAE-DTE) (2reduction to CO. Importantly, irradiating with light of the full range (λ= 250-750 nm) allowed for co-existence of both photoisomers which thereby showed wide spectrum absorption as compared to individual photoisomers, consequently displaying substantially enhanced performance for the photocatalytic CO2reduction. Further, the real-time progress of the CO2reduction reaction and corresponding reaction intermediates was detected by anin situDRIFT experiment.

Development of High-Performance Pyrimidine Nucleoside and Oligonucleotide Diarylethene Photoswitches

Nucleosidic and oligonucleotidic diarylethenes (DAEs) are an emerging class of photochromes with high application potential. However, their further development is hampered by the poor understanding of how the chemical structure modulates the photochromic properties. Here we synthesized 26 systematically varied deoxyuridine- and deoxycytidine-derived DAEs and analyzed reaction quantum yields, composition of the photostationary states, thermal and photochemical stability, and reversibility. This analysis identified two high-performance photoswitches with near-quantitative, fully reversible back-and-forth switching and no detectable thermal or photochemical deterioration. When incorporated into an oligonucleotide with the sequence of a promotor, the nucleotides maintained their photochromism and allowed the modulation of the transcription activity of T7 RNA polymerase with an up to 2.4-fold turn-off factor, demonstrating the potential for optochemical control of biological processes.

Preparation method of near-infrared absorption amphiphilic diene photochromic molecule and reversible photo-thermal method Application of photoacoustic

The invention discloses preparation of a near-infrared absorption amphiphilic diene photochromic molecule and application of reversible photo-thermal and photoacoustic, and belongs to the technical field of functional materials. The structure is as follows. or. In-flight R1 , R2 , R3 Are all selected from C1 - C6 A straight-chain alkyl group. The photochromic protein nanoparticles assembled with albumin can be used for preparing photothermal therapeutic materials and photoacoustic contrast agents.

Diarylethene compound, preparation and applications thereof

The invention relates to a diarylethene compound, preparation and applications thereof, and specificallydiscloses a compound represented by a formula (A), wherein various groups are defined in the specification. According to the invention, the compound is an excellent photochromic compound, and can be subjected to a photoisomerization reaction under the irradiation of light with specific wavelength to generate a ring-closing compound; and the compound and the photoisomerized ring-closing derivative thereof have high activity on agricultural and forestry pests such as aphids, aedes albopictus larvae of NematoceraCulicidae, and the like, and the activity of the ring-closing compound after illumination is higher than the activity of the ring-opening compound before illumination.

Photoswitchable J-aggregated processable organogel by integrating a photochromic acceptor

A novel αchromophoric 1,4-bis(anthracenylethynyl)benzene (BAB)-based highly emissive J-aggregated organogel has been synthesized and characterized. Single-crystal structure determination of asymmetric π-chromophoric bola-amphiphilic BAB1 (dodecyl and triethyleneglycolmonomethylether containing side chains of bis(anthracenylethynyl)benzene) supports J-aggregation. Further, a photochromic acceptor chromophore, 4,4′-(perfluorocyclopent-1-ene-1,2-diyl)bis(5-methylthiophene-2-carbaldehyde), is noncovalently encapsulated in the gel and photoswitching studies have been performed based on photochromic F?rster resonance energy transfer. The modulated emission of the processable soft material is further exploited for rewritable display. However, BAB2 (dodecyl side chain on both sides) does not show gelation property due to its low solubility.

Preparation method of diaryl heterocycle substituted hexafluorocyclopentene-based photochromic compound

The invention relates to a preparation method of a diaryl heterocycle substituted hexafluorocyclopentene-based photochromic compound, and belongs to an organic photochromic material. The preparation method comprises: 1, synthesizing 5-methyl-4-bromo-2-thiophene formaldehyde diethanol; 2, synthesizing 1,2-dimethyl-5-R1-3-bromoindole; and 3, synthesizing a diaryl heterocycle substituted hexafluorocyclopentene-based photochromic compound. According to the present invention, the prepared diaryl heterocycle substituted hexafluorocyclopentene-based photochromic compound has the red shift of the absorption wavelength of 50-100 nm, is a thermally-irreversible bistable state, and can be used in the fields of optical information storage, anti-counterfeiting recognition, concealing materials and military camouflage materials.

Dental Materials With Light-Induced Reversible Coloring

The invention relates to a radically polymerizable dental material having photochromic properties, which contains at least one compound of formula (I) and optionally radically polymerizable monomers, an initiator for radical polymerization and other components.