294213-73-3

Upstream product

• 811-49-4 ethyllithium 
• 1032130-66-7 (2S)-2-(tert-butyldiphenylsilyloxy)pentan-3-ol 

Downstream Products

• 1196867-31-8 (S,Z)-4-(tert-butyldiphenylsilyloxy)pent-2-en-3-yl trifluoromethanesulfonate 
• 302840-37-5 (2S,4R,5R)-2-(tert-butyldiphenylsilyloxy)-5-hydroxy-4,6-dimethyl-3-heptanone 

Relevant academic research and scientific papers

Simple and efficient preparation of enantiopure alkyl α-hydroxyalkyl ketones

The acylation reaction of organolithium reagents with pyrrolidine-derived α-benzyloxy and α-silyloxy carboxamides provides a simple and high-yielding method for the preparation of enantiopure α-benzyloxy and α-silyloxy ketones.

STEREOSELECTIVE SYNTHESIS OF 1-[6-ETHYL-1,2-DIHYDROXY-PROPYL)-PYRIDIN-3-YL]-3-[2-(4-METHYL-PIPERAZIN-1-YL)-BENZYL]-PYRROLIDIN-2-ONE

The present invention is related to the stereospecific preparation of 1-[6-(1- ethyl-1,2-dihydroxy-propyl)-pyridin-3-yl]-3-[2-(4-methyl-piperazin-1-yl)-benzyl]- pyrrolidin-2-one, and the intermediates thereof. Another aspect of the invention relates to 1-[6-(1 -ethyl- 1,2-dihydroxy-propyl)-pyridin-3-yl]-3-[2-(4-methyl-piperazin-1- yl)-benzyl]-pyrrolidin-2-one, wherein the carbon atoms having the 1,2-dihydroxy substituents are any of the four diastereomers selected from (R,R), (R,S), (S,R), and (S, S), wherein the carbon three of the pyrrolidin-2-one is (R) or (S), pharmaceutically acceptable salts thereof, solvates thereof, pharmaceutical compositions containing them, and methods using them for in treating or preventing depression, anxiety, obsessive compulsive disorder (OCD) and other disorders for which a 5-HT1 agonist or antagonist is indicated.