29432-63-1Relevant academic research and scientific papers
THE SPLITTING OF SUBSTANCE P BY THE POST-PROLINE CLEAVING ENZYME FROM LAMB KIDNEYS
Hauzer, Karel,Katzwinkel, Siegfried,Jost, Karel,Barth, Tomislav
, p. 1744 - 1747 (2007/10/02)
The degradation of substance P (an undecapeptide with the following structure: Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2) by the post-proline cleaving enzyme (EC 3.4.21.-) was investigated.The peptide bond between proline and glutamine in positions 4 and 5 of substance P was hydrolyzed in the presence of the enzyme.The tetrapeptide Z-Gly-Pro-Leu-Gly-NH2 was synthetized and used for determining the enzyme actvity during the purification procedure.
