29449-00-1Relevant academic research and scientific papers
Design, synthesis and biological evaluation of nitrofuran-1,3,4-oxadiazole hybrids as new antitubercular agents
Wang, Apeng,Xu, Shijie,Chai, Yun,Xia, Guimin,Wang, Bin,Lv, Kai,Wang, Dan,Qin, Xiaoyu,Jiang, Bin,Wu, Wenhao,Liu, Mingliang,Lu, Yu
, (2021/12/02)
Three series of novel nitrofuran-1,3,4-oxadiazole hybrids were designed and synthesized as new anti-TB agents. The structure activity relationship study indicated that the linkers and the substituents on the oxadiazole moiety greatly influence the activity, and the substituted benzenes are more favoured than the cycloalkyl or heterocyclic groups. Besides, the optimal compound in series 2 was active against both MTB H37Rv strain and MDR-MTB 16883 clinical isolate and also displayed low cytotoxicity, low inhibition of hERG and good oral PK, indicating its promising potential to be a lead for further structural modifications.
SYNTHESIS AND PROPERTIES OF FURAN DERIVATIVES. 4. SYNTHESIS OF 2,5-DISUBSTITUTED 1,3,4-OXADIAZOLES CONTAINING FURAN FRAGMENTS
Karakhanov, R. A.,Kelarev, V. I.,Koshelev, V. N.,Morozova, G. V.,Dibi, Ammar
, p. 208 - 218 (2007/10/03)
The condensation of hydrochloride salts of iminoesters of furan acids with hydrazides of carboxylic acids gives 2,5-disubstituted 1,3,4-oxadiazoles containing furan fragments.Such compounds are also formed in the condensation of hydrazides of 5-R-furan-2-carboxylic acids with hydrochloride salts of carboxylic acid iminoesters.The reaction of furan acids with hydrazine dihydrochloride in polyphosphoric acid gave symmetrically disubstituted 1,3,4-oxadiazoles containing furan fragments.
