29449-65-8Relevant academic research and scientific papers
Rational design of simple organocatalysts for the hsicl3 enantioselective reduction of (E)-n-(1-phenylethylidene)aniline
Burguete, Maria Isabel,García-Verdugo, Eduardo,Luis, Santiago V.,Maciá, María,Martí-Centelles, Vicente,Porcar, Raúl
supporting information, (2021/11/30)
Prolinamides are well-known organocatalysts for the HSiCl3 reduction of imines; however, custom design of catalysts is based on trial-and-error experiments. In this work, we have used a combination of computational calculations and experimental work, including kinetic analyses, to properly understand this process and to design optimized catalysts for the benchmark (E)-N-(1-phenylethylidene)aniline. The best results have been obtained with the amide derived from 4-meth-oxyaniline and the N-pivaloyl protected proline, for which the catalyzed process is almost 600 times faster than the uncatalyzed one. Mechanistic studies reveal that the formation of the component supramolecular complex catalyst-HSiCl3-substrate, involving hydrogen bonding breaking and costly conformational changes in the prolinamide, is an important step in the overall process.
Tripeptides acting on the central nervous system and a process for the preparation thereof
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, (2008/06/13)
The invention relates to new peptide derivatives which act on the central nervous system and correspond to the general formula (I), wherein X is L-norleucyl, L-leucyl, L-norvalyl, D-leucyl, L-prolyl, L-2-aminobutyryl, L-valyl, L-threonyl, L-isoleu
