29460-91-1

Basic information

• Product Name: 2-BUTYL PYRAZINE
• Synonyms: 2-BUTYL PYRAZINE
• CAS NO: 29460-91-1
• Molecular Formula: C₈H₁₂N₂
• Molecular Weight: 136.19
• Product Categories: Pyrazines
• Mol File: 29460-91-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 197.9 °C at 760 mmHg
• Flash Point: 73.5 °C
• Appearance: /
• Density: 0.961 g/cm³
• Storage Temp.: 2-8°C
• PKA: 1.67±0.10(Predicted)
• CAS DataBase Reference: 2-BUTYL PYRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BUTYL PYRAZINE(29460-91-1)
• EPA Substance Registry System: 2-BUTYL PYRAZINE(29460-91-1)

Safety Data

• Hazardous Substances Data: 29460-91-1(Hazardous Substances Data)

Usage

General Description

2-Butyl pyrazine is a chemical compound with a strong, nutty, and roasted odor. It is commonly found in food products such as nuts, coffee, and cocoa, and is often used as a flavoring agent in the food industry. It is also present in tobacco and has been identified as a contributor to the flavor of roasted coffee and cooked beans. Due to its intense odor, it is used in relatively small quantities as a flavor enhancer, giving food products a rich and savory aroma. In addition, 2-butyl pyrazine has been identified as a potential contributor to the characteristic smell of certain fungi, making it of interest to the field of natural products chemistry.

Upstream product

• 290-37-9 1,4-pyrazine 
• 109-72-8 n-butyllithium 
• 14508-49-7 2-chloropyrazin 
• 693-04-9 butyl magnesium bromide 
• 6164-79-0 methyl pyrazine-2-carboxylate 
• 32111-21-0 2-iodopyrazine 
• 109-52-4 valeric acid 

Downstream Products

• 496864-09-6 6-(4-methoxyphenyl)-7-propyl[5H]pyrrolo[2,3-b]-pyrazine 

Relevant articles and documents

Manganese-Catalyzed Kumada Cross-Coupling Reactions of Aliphatic Grignard Reagents with N-Heterocyclic Chlorides

Herein we report the use of manganese(II) chloride for the catalytic generation of C(sp 2)-C(sp 3) bonds via Kumada cross-coupling. Rapid and selective formation of 2-alkylated N-heterocyclic complexes were observed in high yields with use of 3 mol% MnCl 2 THF 1.6 and under ambient reaction conditions (21 °C, 15 min to 20 h). Manganese-catalyzed cross-coupling is tolerant toward both electron-donating and electron-withdrawing functional groups in the 5-position of the pyridine ring, with the latter resulting in an increased reaction rate and a decrease in the amount of nucleophile required. The use of this biologically and environmentally benign metal salt as a catalyst for C-C bond formation highlights its potential as a catalyst for the late-stage functionalization of pharmaceutically active N-heterocyclic molecules (e.g., pyridine, pyrazine).

Homolytic alkylation of heteroaromatic bases : The problem of monoalkylation

The silver-catalyzed decarboxylation of carboxylic acids by persulphate leads to alkyl radicals, which have been utilized for the selective alkylation of heteroaromatic bases. The method is particularly efficient in a water-chlorobenzene two-phase system for two reasons : it considerably increases the selectivity in monoalkylation when more positions of high nucleophilic reactivity (i.e. α and γ) are available in the heterocyclic ring (i.e. quinoline , 4-cyano- and 4-ethylpyridine, pyrazine , quinoxaline etc.) and it determines a much higher efficiency for the radical sources when the silver salt catalysis is deactivated by complexation of the salt with the heterocyclic compound . The high selectivity in monoalkylation has been obtained by the combination of polar effects and the increased lipophilicity of the alkylated product, which makes its extraction from the aqueous solution by the organic solvent easier.