29460-92-2

Usage

Uses

Used in Food and Beverage Industry:
2-Isobutylpyrazine is used as a flavor additive for its strong, peculiar smell that enhances the taste and aroma of various food products, including peas, wine, and coffee. Its presence contributes to the unique flavors of these items, making it a valuable component in the culinary world.
Used in Flavor Enhancement:
2-Isobutylpyrazine is used as a flavor enhancer to impart an earthy or nutty note to food and beverage products. Its potent aroma allows it to be used in minute quantities, making it an efficient and effective ingredient in the flavor industry.
Used in Aroma Research:
Due to its distinctive smell, 2-Isobutylpyrazine is utilized in aroma research to study the impact of specific compounds on the perception of taste and smell. This research can lead to the development of new flavor profiles and understanding of how different compounds interact with our senses.
Used in Insect Studies:
2-Isobutylpyrazine's presence in insects like ladybugs makes it a subject of interest in entomology and chemical ecology. Studying its role in these organisms can provide insights into their defense mechanisms, communication, and ecological interactions.

InChI:InChI=1/C8H12N2/c1-7(2)5-8-6-9-3-4-10-8/h3-4,6-7H,5H2,1-2H3

Upstream product

• 14508-49-7 2-chloropyrazin 
• 5674-02-2 2-methylpropylmagnesium chloride 
• 290-37-9 1,4-pyrazine 
• 503-74-2 3-methylbutyric acid 

Relevant academic research and scientific papers

Manganese-Catalyzed Kumada Cross-Coupling Reactions of Aliphatic Grignard Reagents with N-Heterocyclic Chlorides

Herein we report the use of manganese(II) chloride for the catalytic generation of C(sp 2)-C(sp 3) bonds via Kumada cross-coupling. Rapid and selective formation of 2-alkylated N-heterocyclic complexes were observed in high yields with use of 3 mol% MnCl 2 THF 1.6 and under ambient reaction conditions (21 °C, 15 min to 20 h). Manganese-catalyzed cross-coupling is tolerant toward both electron-donating and electron-withdrawing functional groups in the 5-position of the pyridine ring, with the latter resulting in an increased reaction rate and a decrease in the amount of nucleophile required. The use of this biologically and environmentally benign metal salt as a catalyst for C-C bond formation highlights its potential as a catalyst for the late-stage functionalization of pharmaceutically active N-heterocyclic molecules (e.g., pyridine, pyrazine).

Homolytic alkylation of heteroaromatic bases : The problem of monoalkylation

The silver-catalyzed decarboxylation of carboxylic acids by persulphate leads to alkyl radicals, which have been utilized for the selective alkylation of heteroaromatic bases. The method is particularly efficient in a water-chlorobenzene two-phase system for two reasons : it considerably increases the selectivity in monoalkylation when more positions of high nucleophilic reactivity (i.e. α and γ) are available in the heterocyclic ring (i.e. quinoline , 4-cyano- and 4-ethylpyridine, pyrazine , quinoxaline etc.) and it determines a much higher efficiency for the radical sources when the silver salt catalysis is deactivated by complexation of the salt with the heterocyclic compound . The high selectivity in monoalkylation has been obtained by the combination of polar effects and the increased lipophilicity of the alkylated product, which makes its extraction from the aqueous solution by the organic solvent easier.