29462-24-6Relevant academic research and scientific papers
Synthesis of 2-amino-3-heteroaroylthiophenes and evaluation of their activity as potential allosteric enhancers at the human A1 receptor
Baraldi, Pier Giovanni,Pavani, Maria Giovanna,Shryock, John C.,Moorman, Allan R.,Iannotta, Valeria,Borea, Pier Andrea,Romagnoli, Romeo
, p. 855 - 865 (2004)
2-Amino-3-benzoylthiophenes are allosteric enhancers of agonist binding to the adenosine A1 receptor. New compounds bearing an heteroaroyl instead of the benzoyl moiety at the 3-position of the thiophene were synthesized. The phenyl ring was re
THIENO-PYRIDINE DERIVATIVES AS GABA-B ALLOSTERIC ENHANCERS
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Page/Page column 25, (2008/06/13)
The present invention relates to compounds of formula (I), Wherein R1 to R5 are as defined in the specification which compounds are active on the GABABreceptor and can be used for the manufacture of medicaments useful for treating CNS disorders.
Allosteric adenosine receptor modulators
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Page column 16, (2008/06/13)
The present invention relates to compounds of formula (IA): the preparation thereof, pharmaceutical formulations thereof, and their use in medicine as allosteric adenosine receptor modulators for uses including protection against hypoxia and ischemia induced injury and treatment of adenosine-sensitive cardiac arrhythmias.
