294626-55-4Relevant academic research and scientific papers
Organocatalytic michael addition of nitro esters to a,β-unsaturated aldehydes: Towards the enantioselective synthesis of trans-3-substituted proline derivatives
Han, Man-Yi,Zhang, Yong,Wang, Huai-Zhen,An, Wan-Kai,Ma, Bao-Chun,Zhang, Yuan,Wang, Wei
, p. 2635 - 2640 (2013/01/15)
A facile five-step strategy has been developed for the enantioselective synthesis of trans-3- substituted proline derivatives with high diasteroselectivity (dr>20:1) and enantioselectivity (up to 97% ee). The key step is the asymmetric organocatalytic Michael addition of nitro esters to a,β-unsaturated aldehydes, which affords the chiral Michael adducts in high yields (up to 96%) and excellent enantioselectivity (up to 99% ee) by using diaryl- ACHTUNGTRENUNGprolinol silyl ether as the organocatalyst.
