294634-73-4

Upstream product

• 7436-90-0 2,2-dibromostyrene 
• 78389-87-4 ((trimethylsilyl)ethynyl)zinc(II) chloride 
• 1066-54-2 trimethylsilylacetylene 
• 250643-77-7 tris(2-(trimethylsilyl)ethynyl)indium 

Downstream Products

• 294634-79-0 (Z)-3-bromo-4-phenylbut-3-en-1-yn 
• 121635-25-4 (3E)-3-methyl-4-phenyl-1-trimethylsilyl-3-buten-1-yne 
• 1024597-03-2 (E)-(3,4-diphenylbut-3-en-1-yn-1-yl)trimethylsilane 
• 1033075-66-9 [(E)-3-butyl-4-phenylbut-3-en-1-ynyl]trimethylsilane 
• 1033075-67-0 [(E)-3-benzylidene-5-phenylpenta-1,4-diynyl]trimethylsilane 

Relevant academic research and scientific papers

Palladium-catalysed cross-coupling reactions of triorganoindium reagents with alkenyl halides

The regio- and stereoselectivity of the palladium-catalysed cross-coupling reactions of indium organometallics with stereodefined 1-haloalkenes and 1,1-dihaloalkenes have been studied. Triorganoindium reagents (R3In; R = alkyl, alkenyl, aryl an

Palladium-catalyzed trans-selective alkynylation-alkylation tandem process for the synthesis of (E)-3-alkyl-1-trialkylsilyl-3-alken-1-ynes

The Pd-catalyzed trans-selective monoalkynylation of 1,1-dihalo-1-alkenes with XZnCCSiMe3, where X is Br or Cl, can proceed generally in excellent yields in the presence of Pd(DPEphos)Cl2 or Pd(dppf)Cl 2, and subsequent al

Highly selective synthesis of (E)-3-methyl-1-trialkylsilyl-3-en-1-ynes via trans-selective alkynylation catalyzed by Cl2Pd(DPEphos) and stereospecific methylation with methylzincs catalyzed by Pd(tBu3P)2.

[reaction: see text] trans-Selective (>or=98%) monoalkynylation of 1,1-dibromo-1-alkenes and 1,1-dichloro-1-alkenes catalyzed by Cl(2)Pd(DPEphos) followed by stereospecific methylation with Me(2)Zn or MeZnX (X= Cl or Br) catalyzed by Pd((t)()Bu(3)P)(2) pr

Palladium-catalyzed synthesis of butatrienes

Palladium-catalyzed synthesis of functionalized butatrienes was achieved starting from 2-bromo-1-buten-3-yne derivatives and nucleophiles. The reaction proceeded under very mild conditions giving the products in moderate to good yields. The reactivity of the bromobutenyne substrates was highly dependent on substituents at 1-position. A subtle balance of nucleophilicity and basicity in the nucleophiles was also important for the success of the reactions.