294634-78-9Relevant academic research and scientific papers
Studies on stereoselective Sonogashira coupling of 1,1-dibromo-1-alkene
Uenishi, Jun'Ichi,Matsui, Katsuaki,Ohmiya, Hirohisa
, p. 141 - 149 (2002)
The stereoselective Sonogashira coupling of 1,1-dibromo-1-alkene was described. The use of PdCl2(dppf) as a catalyst with trialkylsilylacetylene in benzene selectively gave the (Z)-bromoenyne (2a) along with small amounts of the enediyne (3a).
Stereocontrolled synthesis of branched enyne by stepwise cross-coupling reactions of 1,1-dibromo-1-alkenes
Uenishi, Jun'ichi,Matsui, Katsuaki
, p. 4353 - 4355 (2007/10/03)
Geometrically pure alkynyl, alkenyl and alkyl substituted branched enynes were prepared by the Sonogashira coupling followed by Sonogashira, Suzuki-Miyaura, and Kumada-Tamao-Corriu coupling reactions.
Palladium-catalyzed synthesis of butatrienes
Ogasawara, Masamichi,Ikeda, Hisashi,Ohtsuki, Kazunori,Hayashi, Tamio
, p. 776 - 777 (2007/10/03)
Palladium-catalyzed synthesis of functionalized butatrienes was achieved starting from 2-bromo-1-buten-3-yne derivatives and nucleophiles. The reaction proceeded under very mild conditions giving the products in moderate to good yields. The reactivity of the bromobutenyne substrates was highly dependent on substituents at 1-position. A subtle balance of nucleophilicity and basicity in the nucleophiles was also important for the success of the reactions.
