294648-89-8

Basic information

• Product Name: Carbamic acid, [(1S)-2-[[6-[([1,1'-biphenyl]-4-ylmethyl)amino]-9-(1-methylethyl)-9H-purin -2-yl]amino]-1-methylethyl]-, 1,1-dimethylethyl ester
• CAS NO: 294648-89-8
• Molecular Formula: C29H37N7O2
• Molecular Weight: 515.658
• Mol File: 294648-89-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1S)-2-[[6-[([1,1'-biphenyl]-4-ylmethyl)amino]-9-(1-methylethyl)-9H-purin -2-yl]amino]-1-methylethyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S)-2-[[6-[([1,1'-biphenyl]-4-ylmethyl)amino]-9-(1-methylethyl)-9H-purin -2-yl]amino]-1-methylethyl]-, 1,1-dimethylethyl ester(294648-89-8)
• EPA Substance Registry System: Carbamic acid, [(1S)-2-[[6-[([1,1'-biphenyl]-4-ylmethyl)amino]-9-(1-methylethyl)-9H-purin -2-yl]amino]-1-methylethyl]-, 1,1-dimethylethyl ester(294648-89-8)

Safety Data

• Hazardous Substances Data: 294648-89-8(Hazardous Substances Data)

Upstream product

• 146552-71-8 (S)-tert-butyl 1-aminopropan-2-ylcarbamate 
• 294648-35-4 N-(biphenyl-4-ylmethyl)-2-chloro-9-isopropyl-9H-purin-6-amine 

Downstream Products

• 294647-11-3 C₂₄H₂₉N₇ 

Relevant articles and documents

Biaryl purine derivatives as potent antiproliferative agents: Inhibitors of cyclin dependent kinases. Part I

The introduction of an aryl ring onto the 4-position of the C-6 benzyl amino group of the Cdk inhibitor roscovitine (2), maintained the potent Cdk inhibition demonstrated by roscovitine (2) as well as greatly improving the antiproliferative activity. A series of C-6 biarylmethylamino derivatives was prepared addressing modifications on the C-6 biaryl rings, N-9 and C-2 positions to provide compounds that displayed potent cytotoxic activity against tumor cell lines. In particular, derivative 21h demonstrated a >750-fold improvement in the growth inhibition of HeLa cells compared to roscovitine (2).