294649-40-4

Upstream product

• 141-97-9 ethyl acetoacetate 
• 57-13-6 urea 
• 122-03-2 (4-isopropylbenzaldehyde) 

Relevant academic research and scientific papers

One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones, thiones and 2-selenoxo DHPMs using 1-butyl-3-methylimidazolium hydrogen sulfate as non-halogenated ionic liquid

1-Butyl-3-methylimidazolium hydrogen sulfate ([BMIM][HSO4]) as a non-halogenated ionic liquid (IL) was used for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and thiones or 2-selenoxo DHPMs in a Biginelli type multi-component reaction. By us

Method for preparing 2-pyrimidinone derivative through oxidative dehydrogenation aromatization

The invention provides a method for preparing a 2-pyrimidinone derivative. The method comprises the following steps of: heating aldehyde, urea, ethyl acetoacetate and a catalyst metal chloride to react to obtain a 3, 4-dihydropyrimidinone derivative, sequ

Zirconium (IV) porphyrin graphene oxide: a new and efficient catalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones

A covalently cross-linked graphene oxide (GO) as a catalyst was prepared by a cross-linking process using the nucleophilic reaction of zirconium (IV)-coordinated 5,10,15,20-tetrakis (aminophenyl)porphyrin (ZrPPh) with carboxyl groups of the edges of GO (GO-ZrPPh). The chemical structure of catalyst was characterized by different analyses such as FT-IR, SEM, TEM, EDS, ICP, TGA and UV. All analyses confirm the occurrence of successfully covalent immobilization of ZrPPh on the GO. Also, TEM and SEM images show that ZrPPh has been immobilized in the both of the edges and the basal plane of GO. The activity of the catalyst was studied for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones via Biginelli reaction. The cross-linked catalyst is able to catalyze the reaction in short reaction times and good to excellent yields.

Br?nsted acidic 1-ethyl-1,2,4-trizolium phenylsulfonate as catalyst for biginelli reaction

A Br?nsted acidic 1-ethyl-1,2,4-triazolium phenylsulfonate has been synthesized and characterized. A catalytic study is performed for 1-ethyl-1,2,4-triazolium phenylsulfonate as acid catalyst for a multicomponent reaction of synthesis of series of 3,4-dih

2-oxo-1,2,3,4-tetrahydropyrimidines ethyl esters as potent β-glucuronidase inhibitors: One-pot synthesis, in vitro and in silico studies

Background: Glucuronidation is essential for the metabolism and excretion of toxic substances. β-Glucuronidase enzyme slows down the process of glucuronidation, and thus plays an important role in the on-set of colorectal carcinoma, and many other disease

Xanthine oxidase inhibitory and molecular docking studies on pyrimidones

Background: Xanthine oxidase is an important enzyme which catalyzes the production of uric acid and superoxide anion from xanthine. The over-production of these products leads to different disease conditions. For instance, uric acid is responsible for hyp

A unique opportunity for the utilization of glass wastes as a resource for catalytic applications: toward a cleaner environment

Although glass recycling has been conducted since 1970s, and even though recycled glass waste has been used in the construction of various alternative products, the utilization of glass waste for catalytic applications has not been fully considered until

Synthesis of 1-alkyl triazolium triflate room temperature ionic liquids and their catalytic studies in multi-component Biginelli reaction

Synthesis of three Brnsted acid-based ionic liquids, namely, 1-ethyl-1,2,4-triazolium triflate (1a), 1-propyl-1,2,4-triazolium triflate (1b) and 1-butyl-1,2,4-triazolium triflate (1c), is described. These ionic liquids have been employed as catalysts for

An appropriate one-pot synthesis of dihydropyrimidinones catalyzed by heteropoly acid supported on zeolite: An efficient and reusable catalyst for the Biginelli reaction

A mild and efficient catalytic method has been developed for the synthesis of 3,4-dihydropyrimidin-2 (1H)-ones (DHPM) by a one-pot three-component cyclocondensation reaction using molybdophosphoric acid (MPA) supported on Y zeolite in high to excellent yi

One-pot synthesis of dihydropyrimidinones by dodecylphosphonic acid as solid Bronsted acid catalyst under solvent-free conditions via Biginelli condensation

Dodecylphosphonic acid is a solid Bronsted acid that catalyzes efficiently the preparation of dihydropyrimidinones by Biginelli condensation under solvent-free conditions. This protocol offers several advantages including high yields, short reaction times