294659-30-6

Basic information

• Product Name: Methyl1-BOC-pyrrole-2-carboxylate
• Synonyms: Methyl1-BOC-pyrrole-2-carboxylate;1-t-Butyl 2-methyl 1H-pyrrole-1,2-dicarboxylate;1-(tert-Butyl)2-methyl1H-pyrrole-1,2-dicarboxylate
• CAS NO: 294659-30-6
• Molecular Formula: C₁₁H₁₅NO₄
• Molecular Weight: 225.2411
• Mol File: 294659-30-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Methyl1-BOC-pyrrole-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl1-BOC-pyrrole-2-carboxylate(294659-30-6)
• EPA Substance Registry System: Methyl1-BOC-pyrrole-2-carboxylate(294659-30-6)

Safety Data

• Hazardous Substances Data: 294659-30-6(Hazardous Substances Data)

Usage

Uses

Methyl 1-BOC-pyrrole-2-carboxylate

Upstream product

• 1193-62-0 methyl Pyrrole-2-carboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 34619-03-9 tert-butyldicarbonate 
• 35302-72-8 pyrrol-2-yl trichloromethyl ketone 

Downstream Products

• 941714-57-4 3-bromo-1H-pyrrole-2-carboxylic acid methyl ester 
• 942070-38-4 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 52635-93-5 methyl 4-(2-nitrophenyl)-1H-pyrrole-2-carboxylate 
• 1193-62-0 methyl Pyrrole-2-carboxylate 
• 59936-29-7 (S)-N-(tert-butoxycarbonyl)proline methyl ester 
• 73323-65-6 1-(tert-butyl) 2-methyl (R)-pyrrolidine-1,2-dicarboxylate 
• 294659-37-3 (2S,3R,4S)-3,4-Bis-benzyloxy-2-benzyloxymethyl-2-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 294659-36-2 (2R,3R,4S)-3,4-Dihydroxy-2-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 
• 294659-39-5 (2S,3R,4S)-3,4-Dihydroxy-2-hydroxymethyl-2-((2R,3R,4S,5R,6S)-3,4,5-tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 294659-35-1 (R)-2-((2R,3R,4S,5R,6S)-3,4,5-Tris-benzyloxy-6-methoxy-tetrahydro-pyran-2-ylmethyl)-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester 

Relevant articles and documents

Rh(II)-Catalyzed Monocyclopropanation of Pyrroles and Its Application to the Synthesis Pharmaceutically Relevant Compounds

Here we report Rh(II)-catalyzed monocyclopropanation reactions on pyrroles in the presence of aryldiazoacetates, providing the corresponding dearomatized products with high levels of enantioselectivity (up to >99% ee). Under the catalysis of Rh2/sub

Technical scale synthesis of a new and highly potent thrombin inhibitor

In this account, we describe the development of an efficient and convergent process for the peptidomimetic thrombin inhibitor 1 on production plant scale. Starting from nicotinonitrile (13), (2S,4R)-1-(tert-butoxycarbonyl)-4-hydroxy-2- pyrrolidinecarboxylic acid (5) and (2R)-2-amino-3-cyclohexylpropanoic acid (29) compound 1 was obtained in 16 chemical steps. New methods had been developed for the preparation of the key intermediate dehydroproline 22 and the transformation of nitriles into amidines. The thrombin inhibitor 1 was isolated by special techniques (nanofiltration and spray drying). Almost all salts of 1 are amorphous, however, a crystalline complex was obtained with 1,2-benzisothiazol-3(2H)-one 1,1-dioxide (Saccharin).