294669-33-3

Upstream product

• 1080564-23-3 2-[2-(benzyloxy)-5-methylphenyl]cyclobutanone 

Downstream Products

• 1080564-12-0 5-(4-cyanophenyl)-7-methyl-4,5-dihydrobenzo[b]oxepin-2(3H)-one 
• 1080564-11-9 5-[4-(ethoxycarbonyl)phenyl]-7-methyl-4,5-dihydrobenzo[b]oxepin-2(3H)-one 
• 1080564-14-2 5-[4-(methoxycarbonyl)-2-methylphenyl]-7-methyl-4,5-dihydrobenzo[b]oxepin-2(3H)-one 

Relevant academic research and scientific papers

Palladium-catalyzed sequential carbon-carbon bond cleavage/formation producing arylated benzolactones

(Chemical Equation Presented) 3-(2-Hydroxyphenyl)cyclobutanones react with aryl bromides in the presence of palladium catalysts to afford 4-arylmethyl-3,4-dihydrocoumarins in high yields through a sequence involving carbon-carbon bond cleavage and formation. In the case of the reaction with 2-(2-hydroxyphenyl)cyclobutanones, five- or seven-membered lactones were produced depending on the presence of an additional substituent at the 2-position.