29480-17-9Relevant academic research and scientific papers
Halogen-Lithium Exchange of Sensitive (Hetero)aromatic Halides under Barbier Conditions in a Continuous Flow Set-Up
Weidmann, Niels,Nishimura, Rodolfo H. V.,Harenberg, Johannes H.,Knochel, Paul
supporting information, p. 557 - 568 (2020/09/18)
A halogen-lithium exchange reaction of (hetero)aromatic halides performed in the presence of various electrophiles such as aldehydes, ketones, Weinreb amides, and imines using BuLi as exchange reagent and a commercially available flow set-up is reported. The organolithiums generated in situ were instantaneously trapped with various electrophiles (Barbier conditions) resulting in the formation of polyfunctional (hetero)arenes. This method enables the functionalization of (hetero)arenes containing highly sensitive functional groups such as esters, which are not tolerated in batch conditions.
Synthesis and cytotoxicity of 4-(2-Adamantyl)phenylalkylamines
Papanastasiou, Ioannis,Riganas, Stefanos,Foscolos, George B.,Tsotinis, Andrew,Akhtar, Samar A.,Khan, Mohsin A.,Rahman, Khondaker M.,Thurston, David E.
, p. 319 - 323 (2015/06/22)
The design and synthesis of 4-(2-adamantyl)phenylalkylamines 1-4 are described and their antiproliferative activity against four different tumor cell lines is reported.
Solvolysis of 2-Aryl-2-chloroadamantanes. A new Y Scale for Benzylic Chlorides
Liu, Kwang-Ting,Sheu, Hun-Chang
, p. 3021 - 3025 (2007/10/02)
A series of 2-aryl-2-chloroadamantanes 2, Ar = 4'-methylphenyl, 4'-fluorophenyl, phenyl, 3'-chlorophenyl, 3'-(trifluoromethyl)phenyl, and 4'-(trifluoromethyl)phenyl, were prepared, and the solvolytic rate constants in 23 solvents were measured.Significant
