29482-57-3Relevant articles and documents
ANTIVIRAL TRIAZOLE DERIVATIVES
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Page/Page column 76-77, (2014/08/07)
The present invention discloses compounds of Formula I: wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the prevention or treatment of HCV infection.
The synthesis and SAR of novel diarylsulfone 11β-HSD1 inhibitors
Yan, Xuelei,Wang, Zhulun,Sudom, Athena,Cardozo, Mario,Degraffenreid, Michael,Di, Yongmei,Fan, Pingchen,He, Xiao,Jaen, Juan C.,Labelle, Marc,Liu, Jinsong,Ma, Ji,McMinn, Dustin,Miao, Shichang,Sun, Daqing,Tang, Liang,Tu, Hua,Ursu, Stefania,Walker, Nigel,Ye, Qiuping,Powers, Jay P.
scheme or table, p. 7071 - 7075 (2011/01/03)
In this communication, human 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitory activities of a novel series of diarylsulfones are described. Optimization of this series resulted in several highly potent 11β-HSD1 inhibitors with excellent pharmacokinetic (PK) properties. Compound (S)-25 showed excellent efficacy in a non-human primate ex vivo pharmacodynamic model.
Structure-based design of substituted diphenyl sulfones and sulfoxides as lipophilic inhibitors of thymidylate synthase
Jones, Terence R.,Webber, Stephen E.,Varney, Michael D.,Reddy, M. Rami,Lewis, Kathleen K.,Kathardekar, Vinit,Mazdiyasni, Hormoz,Deal, Judith,Nguyen, Dzuy,Welsh, Katharine M.,Webber, Stephanie,Johnston, Amanda,Matthews, David A.,Smith, Ward W.,Janson, Cheryl A.,Bacquet, Russell J.,Howland, Eleanor F.,Booth, Carol L. J.,Herrmann, Steven M.,Ward, Robert W.,White, Jennifer,Bartlett, Charlotte A.,Morse, Cathy A.
, p. 677 - 683 (2007/10/03)
Six new diphenyl sulfoxide and five new diphenyl sulfones were designed, synthesized, and tested for their inhibition of human and Escherichia coli thymidylate synthase (TS) and of the growth of cells in tissue culture. The best sulfoxide inhibitor of hum
