294850-87-6Relevant academic research and scientific papers
Discovery and characterization of the N-phenyl-N′-naphthylurea class of p38 kinase inhibitors
Cirillo, Pier F.,Hickey, Eugene R.,Moss, Neil,Breitfelder, Steffen,Betageri, Raj,Fadra, Tazmeen,Gaenzler, Faith,Gilmore, Thomas,Goldberg, Daniel R.,Kamhi, Victor,Kirrane, Thomas,Kroe, Rachel R.,Madwed, Jeffrey,Moriak, Monica,Netherton, Matthew,Pargellis, Christopher A.,Patel, Usha R.,Qian, Kevin C.,Sharma, Rajiv,Sun, Sanxing,Swinamer, Alan,Torcellini, Carol,Takahashi, Hidenori,Tsang, Michele,Xiong, Zhaoming
scheme or table, p. 2386 - 2391 (2009/12/07)
An effort aimed at exploring structural diversity in the N-pyrazole-N′-naphthylurea class of p38 kinase inhibitors led to the synthesis and characterization of N-phenyl-N′-naphthylureas. Examples of these compounds displayed excellent inhibition of TNF-α production in vitro, as well as efficacy in a mouse model of lipopolysaccharide induced endotoxemia. In addition, perspective is provided on the role of a sulfonamide functionality in defining inhibitor potency.
Method of treating mucus hypersecretion
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, (2008/06/13)
The invention relates to the use of p38 kinase inhibitors for the preparation of a pharmaceutical composition suitable for inhalation for the treatment of mucus hypersecretion. Furthermore the invention is directed to pharmaceutical compositions suitable for inhalation comprising p38 kinase inhibitors and to methods for the preparation thereof.
Methods of treating cytokine mediated diseases
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, (2008/06/13)
Disclosed are methods of treating acute and chronic inflammation in the lung caused by inhalation of smoke, endometriosis, Behcet's disease, uveitis, ankylosing spondylitis, pancreatitis, cancer, Lyme disease, sepsis, chronic obstructive pulmonary disease, traumatic arthritis, congestive heart failure and restenosis following percutaneous transluminal coronary angioplasty, known to be cytokine mediated, using aromatic heterocyclic compounds described in WO 00/55139.
