29507-86-6

Basic information

• Product Name: 3-AMINO-6-METHOXYQUINOLINE
• Synonyms: 3-AMINO-6-METHOXYQUINOLINE;3-Amino-6-methoxyquinline;6-methoxy-3-quinolinamine(SALTDATA: HCl);6-methoxy-3-quinolinamine 1HCl;3-QuinolinaMine, 6-Methoxy-;3-AMino-6-Methoxyquionline;6-Methoxyquinolin-3-aMine;6-methoxy-3-Quinolinamine
• CAS NO: 29507-86-6
• Molecular Formula: C10H10N2O
• Molecular Weight: 174.2
• Product Categories: Indole
• Mol File: 29507-86-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 350.7 °C at 760 mmHg
• Flash Point: 165.9 °C
• Appearance: /
• Density: 1.217 g/cm³
• Vapor Pressure: 8.45E-07mmHg at 25°C
• Refractive Index: 1.747
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 5.02±0.14(Predicted)
• CAS DataBase Reference: 3-AMINO-6-METHOXYQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-6-METHOXYQUINOLINE(29507-86-6)
• EPA Substance Registry System: 3-AMINO-6-METHOXYQUINOLINE(29507-86-6)

Safety Data

• Hazardous Substances Data: 29507-86-6(Hazardous Substances Data)

Usage

General Description

3-AMINO-6-METHOXYQUINOLINE is a chemical compound with the molecular formula C10H10N2O. It is an aminoquinoline derivative that is often used in the synthesis and production of pharmaceuticals and agrochemicals. 3-AMINO-6-METHOXYQUINOLINE has a yellowish-brown appearance and is insoluble in water but soluble in organic solvents. 3-AMINO-6-METHOXYQUINOLINE has been studied for its potential therapeutic applications, including its antimalarial and anticancer properties. It is also used as a building block in the synthesis of various heterocyclic compounds and as a fluorescence probe in biological research.

InChI:InChI=1/C8H5BrN2O2/c9-6-4-10-8-5(6)2-1-3-7(8)11(12)13/h1-4,10H

Upstream product

• 71082-47-8 6-methoxyquinoline-3-carboxylic acid 
• 26660-48-0 ethyl 6-methoxyquinoline-3-carboxylate 
• 22931-71-1 ethyl 4-chloro-6-methoxyquinolin-3-carboxylate 
• 77156-78-6 ethyl 4-hydroxy-6-methoxyquinoline-3-carboxylate 
• 104-94-9 4-methoxy-aniline 
• 14036-96-5 3-bromo-6-methoxyquinoline 
• 71083-30-2 6-methoxyquinoline-3-carboxamide 
• 53094-53-4 (E)-3-(4-Methoxy-phenylamino)-2-nitro-propenal 
• 20265-97-8 p-anisidine hydrochloride 
• 159454-58-7 (E)-3-(4-Methoxy-phenylamino)-2-nitro-propenal 
• 159454-73-6 3-nitro-6-methoxyquinoline 

Downstream Products

• 426842-85-5 4-chloro-3-fluoro-6-methoxyquinoline 
• 727650-61-5 3-aminoquinolin-6-ol 
• 1451273-43-0 5-bromo-N-(6-hydroxyquinolin-3-yl)-2-methoxybenzenesulfonamide 
• 1451274-40-0 3-(5-bromo-2-methoxyphenylsulfonamido)quinolin-6-yltrifluoromethanesulfonate 
• 1451273-46-3 3-(5-bromo-2-methoxybenzenesulfonylamino)quinoline-6-carboxylic acid methyl ester 
• 1451273-47-4 3-(5-bromo-2-methoxybenzenesulfonylamino)quinoline-6-carboxylic acid 
• 1451273-48-5 3-(5-bromo-2-methoxybenzenesulfonylamino)quinoline-6-carboxylic acid amide 
• 1451273-49-6 3-(5-bromo-2-methoxybenzenesulfonylamino)quinoline-6-carboxylic acid methylamide 
• 77421-36-4 6-methoxy-3-quinolinol 

Relevant articles and documents

Initial Route Scouting and Final Process Development for the Multi-Kg Production of 3-Fluoro-6-methoxyquinoline from p-Anisidine and 2-Fluoromalonic Acid

A scalable route to 3-fluoro-6-methoxyquinoline needed to be developed as multi-kg amounts of this heterocycle were required. Initial route development focused on the formation of the key C-F bond via a Balz-Schiemann reaction or electrophilic fluorinatio

PYRIMIDINE DERIVATIVES USED AS PI-3 KINASE INHIBITORS

Phosphatidylinositol (PI) 3-kinase inhibitor compounds (I), their pharmaceutically acceptable salts, and prodrugs thereof ; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, and phospholipid kinases.

Novel process for preparing 3-fluoroquinolines

The invention relates to a novel preparation of 3-fluoroquinolines of formula (I) in which R1, R2, R3 and R4 represent: a) a fluorine; b) an alkyl optionally substituted with one to three fluorines, with OR