29528-19-6

Basic information

• Product Name: 2-(1-methyl-1H-benzo[d]imidazol-2-yl)aniline
• Synonyms: 2-(1-methyl-1H-benzo[d]imidazol-2-yl)aniline
• CAS NO: 29528-19-6
• Molecular Weight: 223.277
• Mol File: 29528-19-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(1-methyl-1H-benzo[d]imidazol-2-yl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-methyl-1H-benzo[d]imidazol-2-yl)aniline(29528-19-6)
• EPA Substance Registry System: 2-(1-methyl-1H-benzo[d]imidazol-2-yl)aniline(29528-19-6)

Safety Data

• Hazardous Substances Data: 29528-19-6(Hazardous Substances Data)

Upstream product

• 612-28-2 2-nitro-N-methylaniline 
• 5805-39-0 2-(aminophenyl)benzimidazole 
• 74-88-4 methyl iodide 
• 25148-68-9 N-methylbenzene-1,2-diamine dihydrochloride 
• 3717-99-5 1-methyl-2-(2-nitrophenyl)-2,3-dihydrobenzimidazole 
• 4760-34-3 N-methyl-1,2-phenylenediamine 
• 88-73-3 2-Chloronitrobenzene 
• 60418-17-9 2-(2-azidophenyl)-1-methylbenzimidazole 
• 60418-14-6 1-methyl-2-(2-nitrophenyl)-1H-benzo[d]imidazole 

Downstream Products

• 60418-17-9 2-(2-azidophenyl)-1-methylbenzimidazole 

Relevant articles and documents

Potential apoptosis inducing agents based on a new benzimidazole schiff base ligand and its dicopper(ii) complex

Synthesis, characterization and antiproliferative activity of a new benzimidazole based Schiff base 2-(1-methyl-1-H-benzimidazol-2-yl)phenyl)imino)methyl)phenol (HL) and dicopper(ii) complex [{Cu(L)NO3}2] (CuL) containing L-/su

Potential apoptosis inducing agents based on a new benzimidazole schiff base ligand and its dicopper(ii) complex

Synthesis, characterization and antiproliferative activity of a new benzimidazole based Schiff base 2-(1-methyl-1-H-benzimidazol-2-yl)phenyl)imino)methyl)phenol (HL) and dicopper(ii) complex [{Cu(L)NO3}2] (CuL) containing L-has been described. Both HL and CuL have been meticulously characterized by satisfactory elemental analyses, FT-IR, NMR, ESI-MS, electronic absorption and emission spectroscopy, and their structures unambiguously determined by X-ray single crystal analyses. Titration studies (absorption and emission) revealed interaction of the ligand and its dicopper(ii) complex with DNA/BSA and stronger affinity of the CuL relative to HL. Binding of the HL and CuL with DNA/BSA have been validated by in silico studies and their cytotoxic effect on human breast cancer cell lines (MCF-7) by MTT assay. IC50values (458 μM and 22 μM for HL, CuL) clearly suggested substantial cytotoxicity of the complex CuL toward MCF-7 compared to the ligand HL. Greater antiproliferative efficacy of the CuL in contrast to HL has been evidenced by fluorescence activated cell sorting (FACS) and AO/EB fluorescence staining. The possible mode of the apoptotic pathway for CuL has further been affirmed by reactive oxygen species (ROS) generation studies. This journal is