295316-03-9

Upstream product

• 183741-60-8 indole-1-carbaldehyde diethyl acetal 
• 102-96-5 (2-nitroethenyl)benzene 
• 295316-02-8 1-Diethoxymethyl-2-(2-nitro-1-phenylethyl)indole 

Downstream Products

• 295316-00-6 4-Phenyl-1,2,3,4-tetrahydropyrimido[1,6-a]indole 
• 109315-45-9 2,3,4,5-tetrahydro-4-phenyl-1H-pyrido<4,3-b>indole 
• 295316-04-0 4-Phenyl-3,4-dihydropyrimido[1,6-a]indole 

Relevant academic research and scientific papers

Regiocontrolled annellation reactions starting from diethoxymethyl protected indole

Directed metallation of the diethoxymethyl protected indole 4 followed by treatment with β-nitrostyrene leads to the 1,2- disubstituted indole 5. Using 5 as a central intermediate, the tricyclic annellation products of type 2 and 3 were accessed when the regiochemical outcome of the reactions could be controlled.