295344-52-4

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 126-81-8 dimedone 
• 105-45-3 acetoacetic acid methyl ester 
• 14205-39-1 methyl 3-aminocrotonate 
• 141-97-9 ethyl acetoacetate 

Relevant academic research and scientific papers

Urea as an ammonia surrogate in the hantzsch’s synthesis of polyhydro-quinolines / 1,4-dihydropyridines under green reaction conditions

Synthesis of polyhydroquinolines via Hantzsch’s multicomponent reaction (MCR) involves the use of a hygroscopic and moderately toxic ammonium salt as one of the key reactants. In our effort, we have found urea as an effective ammonia surrogate when the MC

Surfactant-directed one-pot preparation of novel Ti-containing mesomaterial with improved catalytic activity and reusability

Titanium was incorporated in ionic liquid based periodic mesoporous organosilica to prepare a nanostructured catalyst (Ti@PMO-IL) with high activity. Procedure for the synthesis of Ti@PMO-IL was followed according the simultaneous hydrolysis and condensation of alkylimidazolium ionic liquid, tetramethoxysilane (TMOS) and tetrabutylorthotitanate (TBOT) where a surfactant template was used together with a simple acid-based catalytic aproach. N2 adsorption isotherm of the Ti@PMO-IL was studied to measure its mean pore volume, pore size distribution and specific surface area. Diffuse reflectance infrared Fourier transform (DRIFT) spectroscopy was applied to identify the chemical bonds present in Ti@PMO-IL. The morphology of this nanomaterial was investigated by scanning electron microscopy (SEM). Transmission electron microscopy (TEM) image was used to study mesoporosity and structure order of the catalyst. The catalytic activity of Ti@PMO-IL was then studied and found to be efficient and reusable to catalyze Hantzsch reaction.

Sulfuric acid heterogenized on magnetic Fe3O4 nanoparticles: A new and efficient magnetically reusable catalyst for condensation reactions

Immobilized sulfuric acid on magnetic Fe3O4 nanoparticles (Fe3O4 MNPs-OSO3H) as a new solid acid nanocomposite was successfully synthesized and its catalytic activity in a series of condensation reactions was studied. High catalytic activity, simple separation from reaction mixture by an external magnet and good reusability are several eco-friendly advantages of this catalytic system. It is noteworthy that this catalytic system is applicable to a wide range of spectrum of aromatic aldehydes, and the desired products were obtained in good to excellent yields under mild conditions. The use of ecofriendly solvents makes also this synthetic protocol ideal and fascinating from the environmental point of view.

Modified Hantzsch reaction in the presence of chiral organic catalysts

Modified Hantzsch reaction in three- and four-component system in the presence of new chiral organic catalysts was investigated and the advantages of this reaction in three-component system compared to four-component one were demonstrated, the influence o

Chitosan: a sustainable, reusable and biodegradable organocatalyst for green synthesis of 1,4-dihydropyridine derivatives under solvent-free condition

Abstract: Chitosan, a biodegradable green catalyst, was found to be an impressive system for one-pot four-component reaction of different aldehydes, dimedone, β‐ketoesters or acetoacetanilide, and ammonium acetate leading to 1,4-dihydropyridine derivatives via Hantzsch-type condensation under solvent-free condition. This methodology produces diverse superiorities such as operational simplicity, short reaction time, satisfied yield and recyclable catalyst. In this work, we attempted to develop several modifications for the classical Hantzsch conversion to report a novel eco-friendly method that is free from previously reported disadvantages. Graphical Abstract: [Figure not available: see fulltext.]

Sulfonic acid–functionalized Wang resin (Wang-OSO3H) as polymeric acidic catalyst for the ecofriendly multicomponent synthesis of polyhydroquinolines via Hantzsch condensation

An efficient and green approach has been developed for the synthesis of polyhydroquinoline derivatives via Hantzsch condensation reaction directly from corresponding substituted aromatic and aliphatic aldehydes, β-keto compounds, active methylene compound

One-pot multicomponent synthesis hexahydroquinoline derivatives in Triton X-100 aqueous micellar media

A facile and efficient synthesis of hexahydroquinoline derivatives (5a-o) was reported via a four-component condensation reaction of aldehydes, dimedone, methyl aceto acetate and ammonium acetate in the presence of Triton X-100 in water at room temperature. The use of just 20 mol % of Triton X-100 in water solvent is sufficient. The FT-IR, 19F NMR, 1H NMR, 13C NMR spectra and elemental analysis confirm the structure of the compounds.

Cobalt triflate catalyzed one-pot synthesis of fluorophore 1,4-dihydropyridine derivatives via Hantzsch reaction

A wide variety of 1,4-dihydropyridines have been synthesized through one-pot condensation of aromatic aldehydes, β-ketoesters, cyclic 1,3-diones and ammonium acetate using cobalt triflate as a catalyst through Hantzsch reaction. Some of the salient features of the present protocol are shorter reaction time, mild reaction conditions, good yields, non-aqueous work-up, reusability of the catalyst and non-requirement of column chromatographic separation.

FeNH4(SO4)2·12H2O (alum)-catalyzed preparation of 1,4-dihydropyridines: Improved conditions for the Hantzsch reaction

FeNH4(SO4)2-12H2O (alum) efficiently catalyzes the one-pot three-component reaction of dimedone, aldehydes, and 3-aminocrotonate to afford 1,4-dihydropyridines. The work-up is easy, and the products are obtained

Vanadatesulfuric acid-catalyzed novel and eco-benign one-pot synthesis of polyhydroquinoline derivatives under solvent-free conditions

A novel and green approach for efficient and rapid synthesis of biologically active polyhydroquinoline derivatives via unsymmetric Hantzsch reaction using Vanadatesulfuric acid (VSA) as a new and recyclable catalyst under solvent-free conditions was repor