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• 504-02-9 1,3-cylohexanedione 
• 121-33-5 vanillin 
• 105-45-3 acetoacetic acid methyl ester 

Relevant academic research and scientific papers

Nanometasilica disulfuric acid (NMSDSA) and nanometasilica monosulfuric acid sodium salt (NMSMSA) as two novel nanostructured catalysts: applications in the synthesis of Biginelli-type, polyhydroquinoline and 2,3-dihydroquinazolin-4(1H)-one derivatives

Abstract: Nanometasilica disulfuric acid (NMSDSA) and nanometasilica monosulfuric acid sodium salt (NMSMSA) as two nanostructured novel, green and heterogeneous catalysts were designed, synthesized and fully characterized by FT-IR, energy-dispersive X-ray spectroscopy, X-ray diffraction patterns, scanning electron microscopy, transmission electron microscopy and thermal gravimetric analysis. Then their catalytic applications were studied in the Biginelli-type reaction for the synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives via one-pot three-component condensation reaction between several aldehydes, ethyl acetoacetate and urea or thiourea. To further study catalytic properties of NMSDSA and NMSMSA, they were used in the synthesis of polyhydroquinoline and 2,3-dihydroquinazolin-4(1H)-one derivatives under same reaction conditions. NMSDSA and NMSMSA have advantages such as cost-effectiveness, cleaner reaction profile, benign and heterogeneous characters, reusability of the catalysts and being in agreement with the green chemistry protocols. The described nanostructured catalysts have natural-based acids and potential for industrial production. Graphical Abstract: Synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives via Biginelli-type reaction, polyhydroquinolines and 2,3-dihydroquinazolin-4(1H)-ones using NMSDSA and NMSMSA as two novel nanostructured catalysts. [Figure not available: see fulltext.]

Straightforward Hantzsch four- and three-component condensation in the presence of triphenyl(propyl-3-sulfonyl)phosphoniumtrifluoromethanesulfonate {[TPPSP]OTf} as a reusable and green mild ionic liquid catalyst

Triphenyl(propyl-3-sulfonyl)phosphoniumtrifluoromethanesulfonate {[TPPSP]OTf} as a reusable, green and benign ionic liquid catalyst has been used in the Hantzsch four-component (synthesis of polyhydroquinolines) and three-component (synthesis of acridines

Synthesis of the first nano ionic liquid 1-methylimidazolium trinitromethanide {[HMIM]C(NO2)3} and its catalytic use for Hanztsch four-component condensation

A novel, green and reusable nano ionic liquid and catalyst, namely 1-methylimidazolium trinitromethanide {[HMIM]C(NO2)3}, was designed and fully characterized by 1H NMR, 13C NMR, IR, mass, X-ray diffraction patt

Synthesis and antioxidant evaluation of novel 4-aryl-hexahydroquinolines from lignin

A series of 4-aryl-hexahydroquinolines were prepared by Hantzsch reaction using aromatic aldehydes obtained from lignin, 1,3-cyclohexanediones, β-ketoesters and ammonium carbonate. The antioxidant properties of compounds 5a-c and 5g-i were evaluated by two methods: scavenging effect on 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical and scavenging effect on 2,2′-azino-bis(3-ethylenzothiazoline-sulfonic acid) diammonium salt (ABTS+) radical. The results show that the compounds containing a methoxy moiety exhibit good activities. The study suggests that some synthesized compounds may serve as promising leads for the treatment against tumors or other free radical-related diseases.

A facile four component one-pot synthesis of polyhydroquinoline derivatives catalyzed by ionic liquid via modified Hantzsch reaction

An efficient and newer Hantzsch reaction for the synthesis of polyhydroquinoline derivatives have been reported via fourcomponent condensation of aldehydes, cyclic 1,3-diketones, β-keto esters, NH4OAc and catalytic amount of ionic liquid 1-Viny