295357-66-3

Basic information

• Product Name: 2-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)glutaric acid
• Synonyms: 2-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)glutaric acid
• CAS NO: 295357-66-3
• Molecular Weight: 278.265
• Mol File: 295357-66-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)glutaric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)glutaric acid(295357-66-3)
• EPA Substance Registry System: 2-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)glutaric acid(295357-66-3)

Safety Data

• Hazardous Substances Data: 295357-66-3(Hazardous Substances Data)

Usage

General Description

2-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)glutaric acid is a chemical compound with the molecular formula C11H12N2O5. It is an amino acid derivative that contains an isoindole ring and a glutaric acid moiety. 2-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)glutaric acid has potential applications in the field of pharmaceuticals and medical research, particularly in the development of new drugs and treatments. Its chemical structure and properties make it a valuable component in the study of neurodegenerative diseases and psychiatric disorders. Additionally, it may also have potential in the field of organic synthesis and materials science. Further research and exploration of this compound's properties and applications may lead to valuable contributions in various scientific and industrial fields.

Upstream product

• 1198299-50-1 dimethyl 2-(4-amino-2,3-dihydro-1-oxo-1H-isoindol-2-yl)glutarate 
• 98475-07-1 2-bromomethyl-3-nitro-benzoic acid methyl ester 
• 59382-59-1 2-methyl-3-nitro-benzoic acid methyl ester 
• 827026-43-7 2-(4-nitro-1-oxo-1,3-dihydroisoindol-2-yl)glutaric acid dimethyl ester 
• 295357-72-1 2-(4-nitro-1-oxo-1,3-dihydroisoindol-2-yl)glutaric acid 
• 295357-79-8 1-(4-nitro-1-oxoisoindolin-2-yl)propane-1,3-dicarboxylic acid dibenzyl ester 

Downstream Products

• 1198299-64-7 3-[4-(N-benzyloxycarbonyl)amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl]glutaric anhydride 
• 879126-98-4 Lenalidomide 

Relevant articles and documents

Preparation method of lenalidomide

A preparation method of lenalidomide comprises the following steps: 1, reacting a raw material methyl 2-methyl-3-nitro-benzoate with a halogenating reagent to obtain methyl 2-halomethyl-3-nitro-benzoate represented by formula (I); 2, reacting the methyl 2-halomethyl-3-nitro-benzoate with dimethyl D,L-glutamate hydrochloride in the presence of an alkaline compound to obtain dimethyl 3-(7-nitro-1-oxo-1,3-dihydroisoindole-2-yl)glutarate represented by formula (II); 3, hydrolyzing the above compound of formula (II) to obtain 3-(7-nitro-1-oxo-1,3-dihydroisoindole-2-yl)glutaric acid represented by formula (III); 4, reducing the above compound of formula (III) to obtain 3-(7-amino-1-oxo-1,3-dihydroisoindole-2-yl)glutaric acid represented by formula (IV); and 5, carrying out ring closure on the above compound of formula (IV) to obtain lenalidomide represented by formula (V). The method has the advantages of simple process, high safety, cheap and easily available raw materials, good quality of the above product, and suitableness for industrial production.

Substituted 1-oxo- and 1,3-dioxoisoindoline and method of reducing inflammatory cytokine levels

1-Oxo- and 1,3-dioxoisoindolines substituted in the 4- or 5-position of the indoline ring reduce the levels of inflammatory cytokines such as TNFα in a mammal. A typical embodiment is 4-(4-amino-1,3-dioxoisoindolin-2-yl)-4-carbamoylbutanoic acid.