295359-61-4Relevant academic research and scientific papers
Mn(III)-Mediated Regioselective 6-endo-trig Radical Cyclization of o-Vinylaryl Isocyanides to Access 2-Functionalized Quinolines
Liu, Yan,Li, Shi-Jun,Chen, Xiao-Lan,Fan, Lu-Lu,Li, Xiao-Yun,Zhu, Shan-Shan,Qu, Ling-Bo,Yu, Bing
, p. 688 - 694 (2020/01/02)
A Mn(III)-mediated radical cyclization reaction of o-vinylaryl isocyanides and arylboronic acids or diphenylphosphine oxides to access various 2-functionalized quinolines under mild conditions was developed. With the introduction of radical stabilizing substituents (e. g. aryl and methyl group) on vinyl group, this reaction provides a regiospecific 6-endo-trig radical cyclization of o-vinylaryl isocyanides, giving a number of structurally unique and biologically potential 2-functionalized quinoline derivatives.
Synthesis of 2,2′-biquinolines from o-isocyanostyrenes
Kobayashi, Kazuhiro,Yonemori, Junpei,Matsunaga, Akihiro,Kitamura, Taichi,Miyuki, Tanmatsu,Morikawa, Osamu,Konishi, Hisatoshi
, p. 33 - 36 (2007/10/03)
The heating of o-isocyanostyrenes (1) in diglyme at reflux temperature for 2 h afforded the corresponding 2,2′-biquinolines (2) via a coupling/electrocyclic reaction in fair-to-good yields.
The formation of quinolin-2(1H)-ones via electrocyclic reaction of o-isocyanatostyrenes generated in situ from o-isocyanostyrenes
Kobayashi, Kazuhiro,Kitamura, Taichi,Yoneda, Keiichi,Morikawa, Osamu,Konishi, Hisatoshi
, p. 798 - 799 (2007/10/03)
A convenient one-pot preparation of 4-substituted or 3,4-disubstituted quinolin-2(1H)-ones from 2-isocyanostyrene derivatives, which involves mCPBA oxidation to the corresponding isocyanate intermediates followed by electrocyclization, is described.
