295360-04-2Relevant academic research and scientific papers
1,4-Addition reaction of ethyl bromodifluoroacetate to Michael acceptors in the presence of copper powder. Improvement of the reaction using TMEDA as an additive
Sato, Kazuyuki,Nakazato, Sumika,Enko, Hiroko,Tsujita, Hiroaki,Fujita, Katsumi,Yamamoto, Takeya,Omote, Masaaki,Ando, Akira,Kumadaki, Itsumaro
, p. 105 - 107 (2003)
Reaction of ethyl bromodifluoroacetate with a variety of Michael acceptors was tremendously improved by the addition of TMEDA. Using this additive, 1,4-adducts were formed exclusively, and any 1,2-adducts or radical adducts were not obtained. THF or other low boiling solvents can be used as a solvent. This simplifies the work-up of the reaction effectively.
Michael-type reaction of ethyl bromodifluoroacetate with α,β-unsaturated carbonyl compounds in the presence of copper powder
Sato, Kazuyuki,Tamura, Misato,Tamoto, Kei,Omote, Masaaki,Ando, Akira,Kumadaki, Itsumaro
, p. 1023 - 1025 (2000)
We have reported that the reaction of ethyl bromodifluoroacetate (1) with alkenyl iodides in the presence of copper powder gives ethyl alkenyldifluoroacetates. As an extension of this reaction, reaction of 1 with Michael acceptors in the presence of copper powder was examined and found to give 1,4-addition products selectively, unless the acceptor has a group stabilizing a radical intermediate, such as a phenyl group.
Through the use of water or more acid as the additive model mckail addition reaction of the method of preparation of the compound
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Paragraph 0065; 0066; 0067; 0068, (2016/10/07)
The present invention relates to a novel method for preparing a compound represented by chemical formula 1 using water or various acids as an additive in a Michael addition reaction of a Michael receptor represented by chemical formula 2 and a compound re
Highly Improved copper-mediated michael addition of ethyl bromodifluoroacetate in the presence of protic additive
Kim, Bong Chan,Park, Aeri,An, Ji Eun,Lee, Hee Bong,Shin, Hyunik,Lee, Won
, p. 3165 - 3170,6 (2020/08/20)
Copper-mediated Michael addition of ethyl bromodifluoroacetate to Michael acceptors is accompanied by the formation of a substantial amount of byproducts. Elucidation of their structure hinted the cause of their formation, from which we discovered a highl
Reactions of ethyl bromodifluoroacetate in the presence of copper powder
Sato,Omote,Ando,Kumadaki
, p. 509 - 515 (2007/10/03)
We have examined the reaction of ethyl bromodifluoroacetate (1) in the presence of copper powder as a procedure for the synthesis of compounds containing a CF2 group. The complex formed in the above reaction reacted with vinyl or aryl iodides t
