295362-46-8

Upstream product

• 90-02-8 salicylaldehyde 
• 17356-08-0 thiourea 
• 123-54-6 acetylacetone 

Relevant academic research and scientific papers

The biginelli reaction with an imidazolium-tagged recyclable iron catalyst: Kinetics, mechanism, and antitumoral activity

The present work describes the synthesis, characterization, and application of a new ion-tagged iron catalyst. The catalyst was employed in the Biginelli reaction with impressive performance. High yields have been achieved when the reaction was carried ou

Air-stable zirconium (IV)-salophen perfluorooctanesulfonate as a highly efficient and reusable catalyst for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones under solvent-free conditions

An air-stable complex of zirconium (IV)-salophen perfluorooctanesulfonate (1) was successfully synthesized by reacting Zr (salphen)Cl2 and C8F17SO3Ag. Complex 1 was characterized and studied by different techniq

Coumarin-chalcone hybrids targeting insulin receptor: Design, synthesis, anti-diabetic activity, and molecular docking

Four series of thirteen new coumarin-chalcone hybrids (DPCU 1–13, DPCT 1–13, DCCU 1–13 and DCCT 1–13) were designed and synthesized using Biginelli synthesis, Pechmann condensation, Acetylation, and Claisen-Schmidt reactions. Synthesized compounds were te

A novel synthesis and characterization of 1,2,3,4-tetrahydropyrimidin-2(1H)-thiones

We reported the use of Br?nsted acid methane sulfonic acid as a promoter for three component Biginelli cyclocondensation reaction of aryl aldehydes, acetylacetone and thiourea at 120°C to afford the corresponding to 1,2,3,4-tetrahydropyrimidin-2(1H)-thion

Synthesis of 4,5-disubstituted-2-thioxo-1,2,3,4-tetrahydropyrimidines and investigation of their acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase I/II inhibitory and antioxidant activities

A series of tetrahydropyrimidinethiones were synthesized from thiourea, β-diketones and aromatic aldehydes, such as p-tolualdehyde, p-anisaldehyde, o-tolualdehyde, salicylaldehyde and benzaldehyde. These cyclic thioureas showed good inhibitory action agai

Ultrasound-mediated synthesis of 3,4-dihydropyrimidin-2-(1H)-ones (or Thiones) with NaHSO4·H 2O

A fast and efficient Biginelli synthesis of 3,4-dihydropyrimidin-2-(1H)- ones (or thiones) by the reaction of aromatic aldehydes, β-dicarbonyls, and urea/thiourea using NaHSO4·H2O/ultrasound system is presented. The reactions were ca

One-pot synthesis of dihydropyrimidine-thione derivatives using tungstate sulfuric acid (TSA) as a recyclable catalyst

An efficient, simple, and environmentally benign procedure for the one-pot synthesis of 3,4-dihydropyrimidine-2-(1H) thione derivatives that entails the three-component condensation of appropriate aryl aldehydes, β-dicarbonyls, and thiourea in the presenc

Evaluation of dihydropyrimidin-(2H)-one analogues and rhodanine derivatives as tyrosinase inhibitors

A series of dihydropyrimidin-(2H)-one analogues and rhodanine derivatives were synthesized and their inhibitory effects on the diphenolase activity of mushroom tyrosinase were evaluated. The results showed that some of the synthesized compounds exhibited

Efficient P2O5 catalyzed microwave assisted one pot synthesis of substituted dihydropyrimidine-2(1H)-ones

Phosphorus pentaoxide catalyzed and microwave enhanced three component Biginelli reaction of aldehyde, 1,3-dicarbonyl compounds and urea or thiourea under reflux microwave conditions to afford dihydropyrimidin-2-(1H)-ones in excellent yield is described.