29559-34-0

Usage

InChI:InChI=1/C9H15NO/c1-2-5-8-6-3-4-7-10-9(8)11/h2,8H,1,3-7H2,(H,10,11)

Upstream product

• 59239-07-5 2-(2'-propenyl)cyclohexanone oxime 
• 105-60-2 caprolactam 
• 106-95-6 allyl bromide 

Downstream Products

• 1180844-43-2 C₁₅H₁₉NO₂S 
• 1180844-39-6 3-allyl-1-tosylazepan-2-one 

Relevant academic research and scientific papers

Ring-Opening Polymerization of Allyl-Functionalized Lactams

Aliphatic polyamides containing pendent allyl groups were prepared by anionic ring-opening copolymerization of -caprolactam with monomer 1, the substituted lactam 3-(3-propenyl)-2-azepanone. Copolymerization experiments revealed that up to 11 mol % of 1 was integrated successfully into these novel polyamides, which ranged in molecular weight from 27 to 72 kDa. Relative to the well-known commercial polyamide-6 (PA-6), the degree of crystallinity of the copolymers decreased with incorporation of functional monomer. Moreover, the pendent allyl groups afforded rapid access to numerous functional aliphatic polyamides, using photoinitiated thiol-ene chemistry, providing a pathway to cross-linked polyamide films and gels.

Mild Amide-Cleavage Reaction Mediated by Electrophilic Benzylation

An extremely mild method for amide-cleavage by using the triazine-based benzylating reagent 4-(4,6-diphenoxy-1,3,5-triazin-2-yl)-4-benzylmorpholinium trifluoromethanesulfonate (DPT-BM), which spontaneously releases benzyl cation species when being dissolved at room temperature, has been developed. O-Benzylation of the amide with DPT-BM and the subsequent hydrolysis of the resulting intermediate benzyl imidate salt afford the corresponding amine and benzyl ester, which can be converted by hydrogenolysis into a carboxylic acid under neutral conditions. O-Benzylation proceeds depending on both steric and electronic factors around the amide group. Thus, some amides have been selectively cleaved over other amides. Furthermore, intramolecular chemoselective cleavage of an amide group in the presence of an ester group was achieved. Such selective hydrolytic reactions cannot be performed with Meerwein reagents as well as under acidic or basic hydrolytic conditions.

Cyclic amidino agents useful as nitric oxide synthase inhibitors

The current invention discloses useful amidino derivative useful as nitric oxide synthase inhibitors.

Amidino derivatives useful as nitric oxide synthase inhibitors

The current invention discloses useful pharmaceutical compositions containing amidino derivative useful as nitric oxide synthase inhibitors.

Amidino dervatives useful as nitric oxide synthase inhibitors

The current invention discloses useful pharmaceutical compositions containing azepine derivatives useful as nitric oxide synthase inhibitors.

2-Iminohomopiperidinium salts as selective inhibitors of inducible nitric oxide synthase (iNOS)

An attractive approach to the treatment of inflammatory conditions such as osteo- and rheumatoid arthritis, inflammatory bowel disease, and sepsis is through the selective inhibition of human inducible nitric oxide synthase (hiNOS) since localized excess