29560-24-5

Usage

Uses

Used in Pharmaceutical Industry:
(22E)-Ergosta-5,7,22,24(28)-tetrene-3β-ol is used as an active pharmaceutical ingredient for its antifungal properties. It is a derivative of Episterol (E588710), which influences ergosterol biosynthesis, making it a promising candidate for the development of new antifungal drugs.
Used in Cosmetics Industry:
In the cosmetics industry, (22E)-Ergosta-5,7,22,24(28)-tetrene-3β-ol is used as an ingredient in various skincare products for its potential moisturizing and anti-inflammatory effects. Its ability to interact with biopolymers and macromolecules may contribute to its efficacy in improving skin health and appearance.
Used in Research and Development:
(22E)-Ergosta-5,7,22,24(28)-tetrene-3β-ol is also utilized in research and development for its potential applications in drug discovery and the study of steroidal compounds. Its unique structure and properties make it an interesting subject for further investigation and potential development of novel therapeutic agents.
Used in Agricultural Industry:
As an antifungal agent, (22E)-Ergosta-5,7,22,24(28)-tetrene-3β-ol can be employed in the agricultural industry to protect crops from fungal infections, thereby increasing crop yield and reducing the need for chemical fungicides.

Upstream product

• 189080-80-6 3-methyl-2-<(phenylsulfonyl)methyl>-1-butanol 
• 556-82-1 3-methyl-2-buten-1-ol 
• 87080-75-9 3β-(tert-Butyldimethylsilyloxy)-23,24-dinorchola-5,7-dien-22-al 
• 248580-58-7 3β-tert-butyldimethylsilyloxyergosta-5,7,22-triene-5α,8α-(1,4-dioxo-1,2,3,4-tetrahydrophthalazine-2,3-diyl)ergosta-6,22-diene 
• 215022-92-7 tert-Butyl-[(3S,9S,10R,13R,14R,17R)-17-((E)-(R)-1,5-dimethyl-4-methylene-hex-2-enyl)-10,13-dimethyl-2,3,4,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yloxy]-dimethyl-silane 
• 215022-90-5 (22E)-28-iodo-3',5'-dioxo-4'-phenyl-3β-(tert-butyldimethylsilyloxy)-5α,8α<1',2'>-1',2',4'-triazolidino-6,22-ergostadiene 
• 215022-88-1 (22E)-3',5'-dioxo-4'-phenyl-3β-(tert-butyldimethylsilyloxy)-5α,8α<1',2'>-1',2',4'-triazolidino-6,22-ergostadien-28-ol 
• 215022-83-6 benzoic acid 2-benzenesulfonylmethyl-3-hydroxy-3-methyl-butyl ester 
• 215022-84-7 benzoic acid 2-benzenesulfonylmethyl-3-methyl-but-3-enyl ester 
• 215022-86-9 3-methyl-2-(phenylsulfonylmethyl)-1-trimethylsilyloxybutane 
• 215022-82-5 3-methyl-2-(phenylsulfonylmethyl)butane-1,3-diol 
• 215022-85-8 3-methyl-2-(phenylsulfonylmethyl)-3-buten-1-ol 
• 18511-56-3 (3,3-dimethyloxiranyl)methanol 

Downstream Products

• 32230-67-4 3β-benzoyloxy-ergosta-5,7,22t,24(28)-tetraene 

Relevant academic research and scientific papers

Effect of sterol side chain on ion channel formation by amphotericin b in lipid bilayers

Amphotericin B (AmB) is one of the most efficient antimycotic drugs used in clinical practice. AmB interacts with membrane sterols increasing permeability of fungal membranes; however, it is still unclear how AmB selectively recognizes the fungal sterol, ergosterol (Erg), over other sterols in cell membranes. In this study, we investigated the effect of an Erg side chain on AmB activity by testing a series of Erg analogues that shared the same alicyclic structure as Erg but varied in the side chain structure by using the K+ influx assay. The results clearly showed that the sterol side chain is essential for AmB selectivity toward Erg and for the activity of AmB-sterol ion channels. In agreement with our previous findings showing the direct interaction between the drug and Erg, these data suggested that AmB directly recognizes the sterol side chain structure, consequently promoting the formation of ion channels by AmB. Furthermore, the C24 methyl group and Δ22 double bond in the side chain of Erg are equally important for the interaction with AmB. Conformational analysis revealed that the C24 methyl group contributes to the interaction by increasing the van der Waals (VDW) contact area of the side chain, while the Δ22 double bond restricts the side chain conformation to maximize the VDW contact with the rigid AmB aglycone. This study provides direct experimental evidence of the mechanism of AmB selectivity toward fungal Erg.

A convenient method for retro-cycloaddition of adducts from steroidal 5,7-dienes and 4-phenyl-1,2,4-triazolidine-3,5-dione and application to the syntheses of biosynthetic intermediates of ergosterol

Use of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) in boiling xylene was found to be a convenient method for the retro-cycloaddition of adducts of 4- phenyl-1,2,4-triazolidine-3,5-dione (PTAD) with steroidal 5,7-dienes. This process was applied to the synthe