29568-34-1

Basic information

• Product Name: 5-chloro-2-methoxybenzohydroximinoyl chloride
• Synonyms: 5-chloro-2-methoxybenzohydroximinoyl chloride
• CAS NO: 29568-34-1
• Molecular Weight: 220.055
• Mol File: 29568-34-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-chloro-2-methoxybenzohydroximinoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-2-methoxybenzohydroximinoyl chloride(29568-34-1)
• EPA Substance Registry System: 5-chloro-2-methoxybenzohydroximinoyl chloride(29568-34-1)

Safety Data

• Hazardous Substances Data: 29568-34-1(Hazardous Substances Data)

Upstream product

• 135-02-4 ortho-anisaldehyde 
• 29577-53-5 2-Methoxy-benzaldehyde oxime 
• 98545-94-9 5-Chlor-2-methoxy-benzaldoxim 

Downstream Products

• 132648-01-2 3,4-bis-(5-chloro-2-methoxy-phenyl)-furazan 2-oxide 
• 495417-29-3 ethyl 3-(5-chloro-2-methoxyphenyl)-5-methylisoxazole-4-carboxylate 

Relevant articles and documents

Unique structure-activity relationship for 4-isoxazolyl-1,4-dihydropyridines

A series of 4-isoxazolyl-1,4-dihydropyridines (IDs) were prepared and characterized, and their interaction with the calcium channel was studied by patch clamp analysis. The structureactivity relationship (SAR) that emerges is distinct from the 4-aryldihydropyridines (DHPs), and affinity increases dramatically at higher holding potentials. Thus, among the 3′-arylisoxazolyl analogues p-Br > p-Cl ? p-F, and p-Cl > m-Cl > o-Cl ? o-MeO. Four of the analogues were examined by single-crystal X-ray diffractometry, and all were found to adopt an O-exo conformation in the solid state. The calculated barrier to rotation, however, suggests that rotation about the juncture between the heterocyclic rings is plausible under physiological conditions. A variable-temperature NMR study confirmed the computation. With Striessnig's computational sequence homologation procedure, a working hypothesis was derived from the data that explains the unique SAR for IDs.