29571-45-7

Basic information

• Product Name: methyl (2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acetate
• CAS NO: 29571-45-7
• Molecular Formula: C₇H₈N₂O₄
• Molecular Weight: 184.1494
• Mol File: 29571-45-7.mol
• Article Data: 2

Chemical Properties

• Density: 1.311g/cm³
• Refractive Index: 1.492
• CAS DataBase Reference: methyl (2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acetate(29571-45-7)
• EPA Substance Registry System: methyl (2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acetate(29571-45-7)

Safety Data

• Hazardous Substances Data: 29571-45-7(Hazardous Substances Data)

Usage

General Description

Methyl (2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acetate is a chemical compound with the molecular formula C7H8N2O4. It is a pyrimidine derivative with a methyl ester functional group on the 5-position. methyl (2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acetate is commonly used in organic synthesis as a building block for the synthesis of various pharmaceuticals and agrochemicals. Its structure and functional groups make it a versatile intermediate for the production of a wide range of compounds. Methyl (2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acetate is an important chemical in the field of drug discovery and development due to its synthetic utility and potential biological activities.

Upstream product

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Relevant articles and documents

Synthesis of L-analogues of 1-(2',3'-dideoxy-β-D-glycero-pent-2-enofuranosyl)thymine

β-L(-)-2',3'-Dideoxy-3'-thiacytidine (3TC), its 5-fluoro derivative ((-)-FTC), 2',3'-dideoxycytidine (β-L-ddC), and its 5-fluoro derivative (β-L-FddC) have been reported to have anti-HIV and anti-HBV activity. It was of particular interest therefore to develop a series of β-L-d4T analogues bearing several kinds of amino-linker arms at the C-5 position of the pyrimidine moiety in an attempt to find more potent and less toxic anti-HIV agents. In addition, modification of nucleosides with various functional molecules has been attracting wide interest in biological studies since die primary amino groups could be useful for the attachment of either fluorescent dyes or a non-nucleosidic reverse transcriptase inhibitor. These modified nucleosides were evaluated for antiviral activity against HIV-1(LAI) in CEM-SS cells and HIV-1(IIIB) in MT4 cells. Unfortunately, none of the compounds exhibited significant anti-HIV activity at the doses tested.