2958-54-5

Basic information

• Product Name: Benzenamine, 4-[2-(3-pyridinyl)ethyl]-
• CAS NO: 2958-54-5
• Molecular Formula: C13H14N2
• Molecular Weight: 198.268
• Mol File: 2958-54-5.mol

Chemical Properties

• CAS DataBase Reference: Benzenamine, 4-[2-(3-pyridinyl)ethyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenamine, 4-[2-(3-pyridinyl)ethyl]-(2958-54-5)
• EPA Substance Registry System: Benzenamine, 4-[2-(3-pyridinyl)ethyl]-(2958-54-5)

Safety Data

• Hazardous Substances Data: 2958-54-5(Hazardous Substances Data)

Upstream product

• 2958-53-4 3-(4-nitro-styryl)-pyridine 
• 2609-49-6 diethyl p-nitrobenzylphosphonate 

Downstream Products

• 145654-41-7 3-<2-<4-(3-methylthioureido)phenyl>ethyl>pyridine 

Relevant articles and documents

Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus

Antibiotic resistance remains a major global public health threat that requires sustained discovery of novel antibacterial agents with unexploited scaffolds. Structure-activity relationship of the first-generation aryl isonitrile compounds we synthesized led to an initial lead molecule that informed the synthesis of a second-generation of aryl isonitriles. From this new series of 20 compounds, three analogues inhibited growth of methicillin-resistant Staphylococcus aureus (MRSA) (from 1 to 4 μM) and were safe to human keratinocytes. Compound 19, with an additional isonitrile group exhibited improved activity against MRSA compared to the first-generation lead compound. This compound emerged as a candidate worthy of further investigation and further reinforced the importance of the isonitrile functionality in the compounds’ anti-MRSA activity. In a murine skin wound model, 19 significantly reduced the burden of MRSA, similar to the antibiotic fusidic acid. In summary, 19 was identified as a new lead aryl isonitrile compound effective against MRSA.