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Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 504-02-9 1,3-cylohexanedione 
• 105-45-3 acetoacetic acid methyl ester 

Relevant academic research and scientific papers

Periodic mesoporous organosilica with ionic-liquid framework supported manganese: An efficient and recyclable nanocatalyst for the unsymmetric Hantzsch reaction

An efficient approach for the green and rapid synthesis of biologically active substituted polyhydroquinoline derivatives via unsymmetric Hantzsch reaction using an ionic liquid based periodic mesoporous organosilica supported manganese (Mn@PMO-IL) catalyst under solvent-free conditions is described. This catalyst showed high reactivity and selectivity for the preparation of a set of different derivatives of polyhydroquinolines under moderate reaction conditions and short times. Moreover, the catalyst was also recovered and reused several times without important decrease in reactivity and yields. The nitrogen adsorption-desorption and transmission electron microscopy of the recovered catalyst significantly proved the high stability and durability of the catalyst under applied reaction conditions. Furthermore, compared to the classical methodologies, this method consistently illustrated the advantages of short reaction times, low catalyst loading, high yields, easy separation and purification of the products, and high recoverability and reusability of the catalyst.

Mo@GAA-Fe3O4MNPs: a highly efficient and environmentally friendly heterogeneous magnetic nanocatalyst for the synthesis of polyhydroquinoline derivatives

Polyhydroquinolines were efficiently obtained from a sequential four-component reaction between dimedone or 1,3-cyclohexandione, ethyl acetoacetate, or methyl acetoacetate as a β-ketoester, aldehydes, and ammonium acetate, under the catalysis of Mo@GAA-Fe3O4MNPs as a green, effective, recyclable, and environmentally friendly nanocatalyst. Due to its magnetic nature the prepared catalyst can be easily separated from the reaction mixture by an external magnet and reused several times without significant changes in catalytic activity and reaction efficiency. The catalyst was characterized using energy dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD), thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FTIR), vibrating sample magnetometry (VSM), scanning electron microscopy (SEM), and transmission electron microscopy (TEM).

Combined thiourea dioxidewater: An effective reusable catalyst for the synthesis of polyhydroquinolines via hantzsch multicomponent coupling

Thiourea dioxide in water was found to be an efficient and reusable organocatalytic system for the one-pot synthesis of polyhydroquinoline derivatives via the Hantzsch-type coupling of aldehyde, dimedone, acetoacetate, and ammonium acetate under mild reaction conditions. Operational simplicity, the use of an economically affordable catalyst, environmentally benign conditions, high product yields, and reusability of the catalyst system were the advantageous features of the developed method.

P-toluene sulfonic acid catalyzed one-pot synthesis of unsymmetrical 1,4-dihydropyridines derivatives via hantzsch reaction

A simple, inexpensive and efficient one-pot synthesis of a series of unsymmetrical 1,4-dihydropyridines derivatives using p-toluene sulfonic acid as catalyst at room temperature was achieved in excellent yields from the four-component Hantzsch condensation reactions of various aromatic aldehydes, 1,3-cyclohexanedione, methyl acetoacetate (or ethyl acetoacetate) and ammonium acetate in a little methanol (or ethanol). The procedure possesses the advantages of short reaction time, high yields, an environmental friendly procedure as well as easy isolation of products.

Silica sulfuric acid: An efficient and versatile catalyst for one-pot synthesis of substituted 5-Oxo-1,4,5,6,7,8-hexahydroquinoline derivatives

An easy method for synthesis of substituted 5-oxo-1,4,5,6,7,8- hexahydroquinoline derivatives from 5,5-dimethyl-1,3-cyclohexanedione or 1,3-cyclohexanedione, arylaldehyde, methyl acetoacetate and ammonium acetate using silica sulfuric acid as catalyst is