296266-88-1

Usage

Uses

Used in Pharmaceutical Industry:
2,6-Dimethyl-4-(5-methyl-furan-2-yl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester is used as a calcium channel blocker for the treatment of cardiovascular diseases such as hypertension and angina pectoris. Its potential to block calcium channels makes it a valuable compound in managing blood pressure and improving heart function.
Used in Drug Development:
2,6-Dimethyl-4-(5-methyl-furan-2-yl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester is used as a promising candidate for pharmaceutical development due to its improved solubility and stability in its dimethyl ester form. This enhances its potential for formulation into effective drug products.

Upstream product

• 620-02-0 5-Methylfurfural 
• 105-45-3 acetoacetic acid methyl ester 
• 14205-39-1 methyl 3-aminocrotonate 

Relevant academic research and scientific papers

Zn/MCM-41-catalyzed unsymmetrical Hantzsch reaction and the evaluation of optical properties and anti-cancer activities of the polyhydroquinoline products

Abstract: The three-component Hantzsch condensation of various aryl aldehydes, dimedone, and methyl 3-aminocrotonate was investigated in the presence of MCM-41-supported ZnNO3. The polyhydroquinoline products which were obtained under mild cond

Synthesis of 4-thiophen-2′-yl-1,4-dihydropyridines as potentiators of the CFTR chloride channel

The gating of the CFTR chloride channel is altered by a group of mutations that cause cystic fibrosis. This gating defect may be corrected by small molecules called potentiators. Some 1,4-dihydropyridine (DHP) derivatives, bearing a thiophen-2-yl and a furanyl ring at the 4-position of the nucleus, were prepared and tested as CFTR potentiators. In particular, we evaluated the ability of novel DHPs to enhance the activity of the rescued ΔF508-CFTR as measured with a functional assay based on the halide-sensitive yellow fluorescent protein. Most DHPs showed an effect comparable to or better than that of the reference compound genistein. The potency was instead significantly improved, with some compounds, such as 3g, 3h, 3n, 4a, 4b, and 4d, having a half effective concentration in the submicromolar range. CoMFA analysis gave helpful suggestions to improve the activity of DHPs.