296276-75-0Relevant academic research and scientific papers
Synthesis of symmetrical and asymmetrical phenethyl thiourea compounds as nonnucleoside inhibitors of HIV-1 reverse transcriptase
Venkatachalam,Uckun, Faith M.
, p. 2039 - 2056 (2007/10/03)
Synthesis of symmetrical and asymmetrical phenethyl thioureas was accomplished in two steps with an overall yield of 75-80%. Condensation of a substituted phenethyl amine with thiocarbonyldiimidazole, followed by treatment with one more equivalent of the phenethylamine in DMF, yielded the desired symmetrical phenethyl thiourea compound as a crystalline solid. In the case of asymmetrical thiourea derivatives, different amines were selected and condensed using a similar procedure. A series of 45 thioureas was synthesized. Copyright Taylor & Francis, Inc.
An efficient acylation/base-catalyzed cyclization of thioureas affords N,N′-disubstituted thiobarbituric acids
Heath, Perry C.,Huang, Charles Q.,Lowe, Richard F.,McCarthy, James R.,Weigel, Leland O.,Whitten, Jeffery P.
, p. 1607 - 1610 (2007/10/03)
Acylation of 1,3-disubstituted thioureas with methyl malonyl chloride followed by base-catalyzed cyclization leads to the preparation of 1,3-disubstituted-2-thiobarbituric acids in high yield.
