2963-66-8

Basic information

• Product Name: 2-(2-HYDROXYPHENYL)-1H-BENZIMIDAZOLE
• Synonyms: 2-(2-Hydroxyphenyl)-1H-benziMidazole 95%;2-(2-Hydroxyphenyl)benzimidazole;2-(2-HYDROXYMETHYL)-1H-BENZIMIDAZOLE;2-(1H-Benzimidazole-2-yl)phenol, 2-(1H-Benzimidazole-Z-yl)phenol, 2-(1H-Benzoimidazol-2-yl)-phenol;o-(1H-Benzimidazol-2-yl)phenol;O-hydroxyphenylbenzimidazole;Phenol, O-2-benzimidazolyl-;2-(2-benzimidazolyl)phenol
• CAS NO: 2963-66-8
• Molecular Formula: C₁₃H₁₀N₂O
• Molecular Weight: 210.2313
• Product Categories: Benzimidazoles;Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Fluorescent
• Mol File: 2963-66-8.mol
• Article Data: 172

Chemical Properties

• Melting Point: 239-243 °C
• Boiling Point: 444.174 °C at 760 mmHg
• Flash Point: 222.429 °C
• Appearance: White to tan/crystals
• Density: 1.289 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.726
• Solubility: Solubility Insoluble in water; soluble in ethanol
• PKA: 9.23(at 25℃)
• CAS DataBase Reference: 2-(2-HYDROXYPHENYL)-1H-BENZIMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-HYDROXYPHENYL)-1H-BENZIMIDAZOLE(2963-66-8)
• EPA Substance Registry System: 2-(2-HYDROXYPHENYL)-1H-BENZIMIDAZOLE(2963-66-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 2963-66-8(Hazardous Substances Data)

Usage

Uses

2-(2-Hydroxyphenyl)-1H-benzimidazole is a chemical reagent used in pharmaceutical syntheses. Used in the synthesis of selective inhibitors of PI3Kα against human tumor cell lines.

InChI:InChI=1/C13H10N2O/c16-12-8-4-1-5-9(12)13-14-10-6-2-3-7-11(10)15-13/h1-8,16H,(H,14,15)

Upstream product

• 37183-26-9 salicylic acid-(2-nitro-anilide) 
• 90-02-8 salicylaldehyde 
• 95-54-5 1,2-diamino-benzene 
• 3986-98-9 2-thiocoumarin 
• 615-28-1 o-phenylenediamine dihydrochloride 
• 7191-90-4 N-(2-hydroxybenzaldehyde)-1-amino-2-phenyleneimine 
• 91-64-5 coumarin 
• 118-55-8 phenyl Salicylate 
• 88-74-4 2-nitro-aniline 
• 15938-69-9 3,3'-(2-oxo-2-phenylethane-1,1-diyl)bis(4-hydroxy-2H-chromen-2-one) 
• 135-02-4 ortho-anisaldehyde 
• 90-01-7 salicylic alcohol 
• 615-43-0 2-iodophenylamine 
• 615-36-1 2-bromoaniline 

Downstream Products

• 769124-06-3 3,4-benzimidazole-5,6-benzo-2-phenyl-1,3,2-oxazaphosphorinane 
• 94542-63-9 2-(1-benzyl-1H-benzoimidazol-2-yl)-phenol 
• 819074-39-0 2-(2-ethoxy-phenyl)-1-ethyl-1H-benzoimidazole 
• 155228-12-9 1-methoxy-2-(1-methyl-1H-benzimidazol-2-yl)benzene 
• 928624-82-2 3-ethyl-2-(2-hydroxyphenyl)-3H-benzimidazole hydrochloride 
• 1123253-76-8 triphenyltin [2-(1H-benzimidazol-2-yl)phenolate] 
• 1155842-31-1 2-[2-(2-pyrrolidin-1-ylethoxy)phenyl]-1H-benzimidazole 
• 1155842-28-6 2-[2-(2-morpholin-4-ylethoxy)phenyl]-1H-benzimidazole 
• 1155842-29-7 2-[2-(2-piperidin-1-ylethoxy)phenyl]-1H-benzimidazole 
• 1198090-29-7 C₁₃H₉Cl₂N₂O₂P 
• 1198179-79-1 diphenyl-[2-(1H-benzimidazol-2-yl-κN)-phenolate-κO]-boron 
• 1266162-42-8 [Re(p-NC₆H₄CH₃)Br₂(2-(2-oxyphenyl)-1H-benzimidazole)(PPh₃)] 
• 1266162-41-7 [Re(p-NC₆H₄CH₃)Cl₂(2-(2-oxyphenyl)-1H-benzimidazole)(PPh₃)] 
• 1290113-06-2 [Co(II)(2-(1H-benzimidazol-2-yl)phenolato)2]*(2-(1H-benzimidazol-2-yl)phenol)*(methanol) 

Relevant articles and documents

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Photopromoted oxidative cyclization of an o-phenylene-bridged Schiff base via a manganese(III) complex, leading to a fluorescent compound, 2-(2-hydroxyphenyl)benzimidazole

Visible light photolysis of [N,N′-o-phenylenebis-(salicylideneaminato)]diaquamanganese(III) resulted in the fluorescent compound 2-(2-hydroxyphenyl)benzimidazole by a one electron redox reaction between MnIII and the Schiff base ligand, followe

A new benzimidazole-based selective and sensitive ‘on–off’ fluorescence chemosensor for Cu2+ ions and application in cellular bioimaging

Two new twinborn benzimidazole derivates (L and A), which bonded pyridine via the ester space on the opposite and adjacent positions of the benzene ring of benzimidazole respectively, were designed and synthesized. Compound L displayed fluorescence quench

Structures, photoluminescence and theoretical studies of two Zn II complexes with substituted 2-(2-hydroxyphenyl)benzimidazoles

Two new ZnII complexes of 2-(2-hydroxyphenyl)benzimidazole (Hpbm), and 5-ammo-2-(1H-benzoimidazol-2-yl)phenol (Hapbm), namely [Zn(pbm) 2] (1), and [Zn(apbm)2]· C2H 5OH·H2O (2), as well as t

Spectral studies on benzimidazole-based “bare-eye” probe for the detection of Ni2+: Application as a solid state sensor

The colorimetric chemosensors for metal ion sensing containing azo group (–N[dbnd]N–) as a chromogenic signaling unit and 2-(2′-hydroxyphenyl)benzimidazole as binding unit are reported. Compound 2 and 3 were studied as metal ion chemosensors in the presen

Syntheses, crystal structures, and properties of nickel and cadmium complexes containing imidazole derivatives

[Ni3(C13H9N2O) 5(CH3OH)2] (1) and [Cd(C12H 8N3)3] (2) were synthesized in methanol and characterized by elemental analyses, IR spectra

Synthesis and fluorescent properties of 2-(1H-benzimidazol-2-yl)-phenol derivatives

A high yield one pot synthesis of 2-(2-hydroxyaryl)-1H-benzimidazole derivatives by 2-hydroxy aromatic aldehydes with aromatic 1,2-diamines in the presence of manganese(III) acetate at room temperature was developed. Nine fluorescencers 2-(2-hydroxyaryl)-1H-benzimidazoles with substituent(s) X (X = H, CH3, CH3O, Cl) and two fluorescencers 2-(2-hydroxyaryl)-1H-naphth[2,3-d]imidazoles with substituent of H or Cl were prepared in 38-87% yield and the ultraviolet absorption and fluorescent spectra of the eleven compounds synthesized were measured in methanol. The fluorescent characteristics of the 2-(2-hydroxyaryl)benzimidazole derivatives prepared were investigated on the basis of excited-state intramolecular proton transfer mechanism, Stokes' shift, quantum yield, and the relationship between fluorescent intensity and the substituents were derived.

Synthesis and characterization of binuclear manganese(IV,IV) and mononuclear cobalt(II) complexes based on 2-(2-hydroxyphenyl)-1H-benzimidazole

The bidentate benzimidazolic hpbm (1), [2-(2-hydroxyphenyl)-1H-benzimidazole], was obtained under mild conditions, and its corresponding metal complexes, di-μ-oxo dimanganese(IV,IV) [Mn2O2(hpbm)4 · 2Py · 5H2O] (

Design, preparation, biological investigations and application of a benzoguanamine-based nickel complex for the synthesis of benzimidazoles

The new magnetic-supported benzoguanamine-based nickel complex was prepared, characterized by various procedures and used as a capable heterogeneous nano-catalyst for the synthesis of diverse 2-phenyl-1H-benzo[d]imidazoles from the reaction o-phenylenedia

Synthesis and evaluation of 2-aryl-1H-benzo[d]imidazole derivatives as potential microtubule targeting agents

Microtubule targeting agents (MTAs) are the potential drug candidates for anticancer drug discovery. Disrupting the microtubule formation or inhibiting the de-polymerization process by a synthetic molecule can lead to an excellent anticancer drug candidat