2963-66-8

Usage

Uses

Used in Pharmaceutical Synthesis:
2-(2-Hydroxyphenyl)-1H-benzimidazole is used as a chemical reagent in the synthesis of selective inhibitors of PI3Kα against human tumor cell lines. Its unique structure allows for the development of targeted therapies that can effectively inhibit the activity of PI3Kα, a key enzyme involved in cell growth and survival, and is often overactivated in various types of cancer.
Used in Cancer Research:
In addition to its use in pharmaceutical synthesis, 2-(2-Hydroxyphenyl)-1H-benzimidazole can also be employed as a research tool in cancer biology. It can be used to study the role of PI3Kα in tumorigenesis and to identify potential therapeutic targets for the development of novel anticancer drugs.
Used in Drug Discovery:
2-(2-HYDROXYPHENYL)-1H-BENZIMIDAZOLE can be utilized in drug discovery efforts to identify new lead compounds with potential anticancer properties. Its unique structure and reactivity make it a valuable starting point for the design and synthesis of novel inhibitors targeting PI3Kα and other related enzymes.
Used in Medicinal Chemistry:
2-(2-Hydroxyphenyl)-1H-benzimidazole can be employed in medicinal chemistry to explore the structure-activity relationships of PI3Kα inhibitors. By systematically modifying the structure of 2-(2-HYDROXYPHENYL)-1H-BENZIMIDAZOLE, researchers can gain insights into the factors that contribute to the potency and selectivity of these inhibitors, ultimately leading to the development of more effective cancer therapies.

InChI:InChI=1/C13H10N2O/c16-12-8-4-1-5-9(12)13-14-10-6-2-3-7-11(10)15-13/h1-8,16H,(H,14,15)

Upstream product

• 37183-26-9 salicylic acid-(2-nitro-anilide) 
• 90-02-8 salicylaldehyde 
• 95-54-5 1,2-diamino-benzene 
• 3986-98-9 2-thiocoumarin 
• 615-28-1 o-phenylenediamine dihydrochloride 
• 607-71-6 4-methyl-2H-chromen-2-one 
• 25624-32-2 4-methyl-2H-1-benzopyran-2-thione 
• 91-64-5 coumarin 
• 118-55-8 phenyl Salicylate 
• 3156-43-2 2-(2-nitro-vinyl)-phenol 
• 3679-66-1 N-(2-aminophenyl)salicylamide 
• 88-74-4 2-nitro-aniline 
• 90-01-7 salicylic alcohol 
• 364625-03-6 4b,9b-dihydroxy-4bH-benzo[d]indeno[1,2-b]furan-10(9bH)-one 

Downstream Products

• 88016-55-1 2-(2-Butoxy-phenyl)-1H-benzoimidazole 
• 88016-56-2 2-(2-Octyloxy-phenyl)-1H-benzoimidazole 
• 88016-57-3 2-(2-Dodecyloxy-phenyl)-1H-benzoimidazole 
• 60178-58-7 2-(2'-(4-methylphenyl)sulfonamidophenyl)benzimidazole 
• 769124-06-3 3,4-benzimidazole-5,6-benzo-2-phenyl-1,3,2-oxazaphosphorinane 
• 819074-39-0 2-(2-ethoxy-phenyl)-1-ethyl-1H-benzoimidazole 
• 155228-12-9 1-methoxy-2-(1-methyl-1H-benzimidazol-2-yl)benzene 
• 928624-82-2 3-ethyl-2-(2-hydroxyphenyl)-3H-benzimidazole hydrochloride 
• 1123253-76-8 triphenyltin [2-(1H-benzimidazol-2-yl)phenolate] 

Relevant academic research and scientific papers

Synthesis, characterization and DPPH scavenging activity of some benzimidazole derivatives

A base-catalyzed conversion of aldehydes to benzimidazoles has been achieved. The compounds have been characterized by IR, NMR, micoranalysis, and GC-MS. The reaction for the formation of benzimidazoles has been monitored with 1H NMR and IR. Th

Photopromoted oxidative cyclization of an o-phenylene-bridged Schiff base via a manganese(III) complex, leading to a fluorescent compound, 2-(2-hydroxyphenyl)benzimidazole

Visible light photolysis of [N,N′-o-phenylenebis-(salicylideneaminato)]diaquamanganese(III) resulted in the fluorescent compound 2-(2-hydroxyphenyl)benzimidazole by a one electron redox reaction between MnIII and the Schiff base ligand, followe

2-(2'-Hydroxyphenyl)benzothiazoles, -benzoxazoles, and -benzimidazoles for Plastic Scintillation Applications

A new series of fluorescent compounds has been tested as dopants for plastic scintillation applications.Several 2-(2'-hydroxyphenyl)benzothiazole, -benzoxazole, and -benzimidazole derivative have been prepared and studied in a polystyrene matrix.Each deri

A new benzimidazole-based selective and sensitive ‘on–off’ fluorescence chemosensor for Cu2+ ions and application in cellular bioimaging

Two new twinborn benzimidazole derivates (L and A), which bonded pyridine via the ester space on the opposite and adjacent positions of the benzene ring of benzimidazole respectively, were designed and synthesized. Compound L displayed fluorescence quench

Simple naked-eye ratiometric and colorimetric receptor for anions based on azo dye featuring with benzimidazole unit

A simple, tailor made receptor 2 based on azo dye featuring with benzimidazole unit with hybrid -OH and -NH binding sites was synthesized and characterized. The addition of CN-, AcO-, F-, and H2PO4su

Structures, photoluminescence and theoretical studies of two Zn II complexes with substituted 2-(2-hydroxyphenyl)benzimidazoles

Two new ZnII complexes of 2-(2-hydroxyphenyl)benzimidazole (Hpbm), and 5-ammo-2-(1H-benzoimidazol-2-yl)phenol (Hapbm), namely [Zn(pbm) 2] (1), and [Zn(apbm)2]· C2H 5OH·H2O (2), as well as t

Complexes containing benzimidazolyl-phenol ligands and Ln(III) ions: Synthesis, spectroscopic studies and preliminary cytotoxicity evaluation

Fourteen new complexes were obtained from Ln(III)(NO3)3?n-H2O and the chromophores 2-(1H-benzo[d]imidazol-2-yl)-phenol (Bzp1) or 2-(5-methyl-1H-benzo[d]imidazol-2-yl)-phenol (Bzp2). The complete characterization allowed us

Spectral studies on benzimidazole-based “bare-eye” probe for the detection of Ni2+: Application as a solid state sensor

The colorimetric chemosensors for metal ion sensing containing azo group (–N[dbnd]N–) as a chromogenic signaling unit and 2-(2′-hydroxyphenyl)benzimidazole as binding unit are reported. Compound 2 and 3 were studied as metal ion chemosensors in the presen

Synthesis, thermoanalysis, and thermal kinetic thermogravimetric analysis of transition metal Co(II), Ni(II), Cu(II), and Zn(II) complexes with 2-(2-Hydroxyphenyl)benzimidazole (HL)

Four complexes with general formulas MIIL2· CH3OH (M = Co, Zn) and MIIL2 (M = Ni, Cu) were synthesized by transition metal ions MII (Co, Ni, Cu, Zn) reacting with 2-(2-hydroxyphenyl)benzimi

Syntheses, crystal structures, and properties of nickel and cadmium complexes containing imidazole derivatives

[Ni3(C13H9N2O) 5(CH3OH)2] (1) and [Cd(C12H 8N3)3] (2) were synthesized in methanol and characterized by elemental analyses, IR spectra