29635-97-0

Basic information

• Product Name: PHENYLTHIOHYDANTOIN TRYPTOPHAN)
• Synonyms: 4-Imidazolidinone,5-(1H-indol-3-ylmethyl)-3-phenyl-2-thioxo-, (S)-; Hydantoin, 5-(indol-3-ylmethyl)-3-phenyl-2-thio-,L- (8CI); L-Tryptophan phenylthiohydantoin; PTH-L-tryptophan;Phenylthiohydantoin-L-tryptophan
• CAS NO: 29635-97-0
• Molecular Formula: C₁₈H₁₅N₃OS
• Molecular Weight: 321.3962
• Mol File: 29635-97-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 517.8°C at 760 mmHg
• Flash Point: 266.9°C
• Appearance: /
• Density: 1.41g/cm³
• Vapor Pressure: 7.95E-11mmHg at 25°C
• Refractive Index: 1.767
• CAS DataBase Reference: PHENYLTHIOHYDANTOIN TRYPTOPHAN)(CAS DataBase Reference)
• NIST Chemistry Reference: PHENYLTHIOHYDANTOIN TRYPTOPHAN)(29635-97-0)
• EPA Substance Registry System: PHENYLTHIOHYDANTOIN TRYPTOPHAN)(29635-97-0)

Safety Data

• Hazardous Substances Data: 29635-97-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H15N3OS/c22-17-16(10-12-11-19-15-9-5-4-8-14(12)15)20-18(23)21(17)13-6-2-1-3-7-13/h1-9,11,16,19H,10H2,(H,20,23)/t16-/m0/s1

Upstream product

• 49645-33-2 phenyl thioisocyanate 
• 103-72-0 phenyl isothiocyanate 
• 4299-70-1 L-tryptophan methyl ester 
• 73-22-3 L-Tryptophan 

Downstream Products

• 126530-33-4 (S)-3-(1H-Indol-3-yl)-N-methyl-2-(3-phenyl-thioureido)-propionamide 

Relevant articles and documents

C ring may be dispensable for β-carboline: Design, synthesis, and bioactivities evaluation of tryptophan analog derivatives based on the biosynthesis of β-carboline alkaloids

According to our previous work and the latest research on the biosynthesis of β-carboline, and using the reverse thinking strategy, tryptophan, the biosynthesis precursor of β-carboline alkaloids, and their derivatives were synthesized, and their biological activities and structure-activity relationships were studied. This bioassay showed that these compounds exhibited good inhibitory activities against tobacco mosaic virus (TMV); especially (S)-2-amino-3-(1H-indol-3-yl)-N-octylpropanamide (4) (63.3 ± 2.1%, 67.1 ± 1.9%, 68.7 ± 1.3%, and 64.5 ± 3.1%, 500 μg/mL) exhibited the best antiviral activity both in vitro and in vivo. Compound 4 was chosen for the field trials and the acute oral toxicity test, the results showed that the compound exhibited good anti-TMV activity in the field and low acute oral toxicity. We also found that these compounds showed antifungal activities and insecticidal activities.