29644-97-1

Basic information

• Product Name: α-(p-Aminophenyl)butyric acid
• Synonyms: 2-(p-aminophenyl)-butyric acid;2-(4-aminophenyl)butanoic acid;2-(4-Aminophenyl)butyric acid;1-alpha-(p-Aminophenyl)butyric acid;Aids019033;Aids-019033;Butyric acid, 2-(p-aminophenyl)-;NSC 27530
• CAS NO: 29644-97-1
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.21572
• Mol File: 29644-97-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 142-143℃
• Boiling Point: 354.6 °C at 760 mmHg
• Flash Point: 168.3 °C
• Appearance: /
• Density: 1.171±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 1.22E-05mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.01±0.10(Predicted)
• CAS DataBase Reference: α-(p-Aminophenyl)butyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: α-(p-Aminophenyl)butyric acid(29644-97-1)
• EPA Substance Registry System: α-(p-Aminophenyl)butyric acid(29644-97-1)

Safety Data

• Hazardous Substances Data: 29644-97-1(Hazardous Substances Data)

Usage

General Description

α-(p-Aminophenyl)butyric acid is a chemical compound with the molecular formula C10H13NO2. It belongs to the class of aminobutyric acids and is structurally similar to the neurotransmitter gamma-aminobutyric acid (GABA). The compound possesses a phenyl group and an amino group attached to the fourth carbon of the butyric acid side chain. It is used as a ligand in medical research and pharmaceutical applications, particularly in the development of GABA receptor modulators and potential therapeutic agents for neurological disorders. α-(p-Aminophenyl)butyric acid is also studied for its potential role in modulating GABAergic neurotransmission and has been investigated for its anxiolytic and anticonvulsant properties.

InChI:InChI=1/C10H13NO2/c1-2-9(10(12)13)7-3-5-8(11)6-4-7/h3-6,9H,2,11H2,1H3,(H,12,13)

Upstream product

• 94814-82-1 2-(4-nitrophenyl)butanonitrile 
• 769-68-6 2-phenylbutanenitrile 
• 7463-53-8 2RS-(4-nitrophenyl)butanoic acid 

Downstream Products

• 29645-00-9 4-Chlorophenylbutyric acid 
• 94232-67-4 2-[4-(1,3-dioxo-2-isoindolinyl)phenyl]butyric acid 
• 141427-21-6 2-(4'-benzamidophenyl)butyric acid 
• 99070-18-5 2-(4-bromophenyl)butanoic acid 

Relevant articles and documents

Preparation process for indobufen intermediate

The invention belongs to the field of drug synthesis, and specifically discloses a preparation process for an indobufen intermediate. With the preparation process provided by the invention, hydrazinehydrate and iron oxyhydroxide are adopted to reduce 2-(4-nitrophenyl)butyric acid; and an obtained product reaches a purity of 99.5% or more and a yield of 99.0% or more. The preparation process provided by the invention only uses water as a reaction solvent, has simple synthesis process and post-treatment operation, is safe and environmentally-friendly, has low cost, improves the yield of a reaction and the purity of a product, and is applicable to industrial production.

NOVEL FUNCTIONALIZED N,N-DIALKYLAMINO PHENYL ETHERS AND THEIR METHOD OF USE

Pharmaceutical compositions of the invention comprise functionalized N,N-dialkylamino phenyl ethers derivatives having a disease-modifying action in the treatment of diseases associated with lysosomal storage dysfunction that include Gaucher's disease, and any disease or condition involving lysosomal storage dysfunction.

OXIDANT SENSITIVE AND INSENSITIVE AROMATIC ESTERS AS INHIBITORS OF HUMAN NEUTROPHIL ELASTASE

2-Phenylalkanoate esters which are useful as inhibitors of human leukocyte elastase.