29652-99-1

Basic information

• Product Name: Benzene, 4-methyl-1-(1-methylethyl)-2-(2-propenyloxy)-
• CAS NO: 29652-99-1
• Molecular Formula: C13H18O
• Molecular Weight: 190.285
• Mol File: 29652-99-1.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Benzene, 4-methyl-1-(1-methylethyl)-2-(2-propenyloxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 4-methyl-1-(1-methylethyl)-2-(2-propenyloxy)-(29652-99-1)
• EPA Substance Registry System: Benzene, 4-methyl-1-(1-methylethyl)-2-(2-propenyloxy)-(29652-99-1)

Safety Data

• Hazardous Substances Data: 29652-99-1(Hazardous Substances Data)

Upstream product

• 89-83-8 thymol 
• 1200591-18-9 C₁₄H₁₈O₃ 
• 106-95-6 allyl bromide 

Downstream Products

• 101041-57-0 2-Allyl-3-methyl-6-isopropyl-phenol 
• 773897-93-1 4-allyloxy-5-isopropyl-2-methyl-benzenesulfonic acid 

Relevant articles and documents

A regioselective synthesis of novel functionalized organochalcogen compounds by chalcogenocyclofunctionalization reactions based on Chalcogen halides and natural products

The regioselective synthesis of novel functionalized condensed organochalcogen compounds by chalcogenocyclofunctionalization reactions based on chalcogen halides and the natural products thymol and carvacrol has been developed. The reactions of selenium d

Synthesis and bio-evaluation of human macrophage migration inhibitory factor inhibitor to develop anti-inflammatory agent

Macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine, is involved in the development of an array of inflammatory disorders including rheumatoid arthritis, inflammatory bowel disease, psoriasis, multiple sclerosis and sepsis. The synthesis of MIF-inhibitor is a rationale approach to develop novel anti-inflammatory agent to treat multitude of inflammatory diseases. In this work, we have synthesized and evaluated MIF-inhibitory activity of a series of small molecules containing isoxazoline skeleton. Mode of binding of this inhibitor to human MIF (huMIF) was determined by docking studies. The synthesized molecules inhibit tautomerase activity of huMIF. The anti-inflammatory activity of the most active inhibitor, 4-((3-(4-hydroxy-3- methoxyphenyl)-4, 5-dihydroisoxazol-5-yl) methoxy) benzaldehyde (4b) was evaluated against huMIF-induced inflammation in a cellular model (RAW 264.7 cell). Compound 4b significantly inhibits huMIF-mediated NF-κB translocation to the nucleus, up-regulation of inducible nitric oxide synthase and nitric oxide production in RAW 264.7 cell which are the markers for inflammation. The compound 4b is not cytotoxic as evident from cell viability assay. Hence, the compound 4b has potential to be a novel anti-inflammatory agent.

A new synthesis of benzofurans from phenols via claisen rearrangement and ring-closing metathesis

Based on Claisen rearrangement, the double bond isomerization of O-allyl function together with the formation of O-vinyl function in one pot, and ring-closing metathesis (RCM), various phenols were transformed into various benzofurans in good yields.