29667-75-2Relevant articles and documents
Preparation of 2-(3-aminopropyl)-cycloalkylamines
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, (2008/06/13)
A process for the preparation of a 2-(3-aminopropyl)-cycloalkylamine of the general formula I STR1 in which the subscript n is an integer from 1 to 4, from a 2-(2-cyanoethyl)-cycloalkanone of the general formula II STR2 in which the subscript n has the meaning stated, wherein the following stages are carried out in discrete reaction chambers: a) the 2-(2-cyanoethyl)-cycloalkanone of formula II is reacted in a first reaction chamber with excess ammonia over an acidic heterogeneous catalyst at a temperature from 20° to 150° C. and a pressure of from 15 to 500 bar, and b) in a second reaction chamber, the reaction product from stage a) is hydrogenated at a temperature of from 60° to 150° C. and a pressure of from 50 to 300 bar in the presence of excess ammonia over a catalyst containing cobalt, nickel, ruthenium, and/or some other noble metal, which catalyst optionally contains a basic component or is supported on neutral or basic supporting material.
