296793-00-5

Upstream product

• 141-97-9 ethyl acetoacetate 
• 121-33-5 vanillin 
• 109-77-3 malononitrile 
• 79785-97-0 hydrazine hydrate 
• 7803-57-8 hydrazine hydrate 
• 4344-87-0 3-hydroxy-5-methyl-1H-pyrazole 
• 105-45-3 acetoacetic acid methyl ester 
• 108-26-9 3-methyl-2-pyrazoline-5-one 

Relevant academic research and scientific papers

An efficient four-component, one-pot synthesis of 6-amino-4-aryl-3-methyl- 2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles under phase-transfer catalyst

A series of 6-amino-4-aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5- carbonitriles (5a-5j) were synthesized by four-component one-pot reaction of methyl acetoacetate (or ethyl acetoacetate), hydrazine hydrate, arylaldehydes and malononitrile in the pre

Synthesis of 6-amino-4-(4-methoxyphenyl)-5-cyano-3-methyl-1-phenyl-1,4- dihydropyrano[2,3-c]pyrazoles using disulfonic acid imidazolium chloroaluminate as a dual and heterogeneous catalyst

In this work, disulfonic acid imidazolium chloroaluminate {[Dsim]AlCl 4} is applied as a new acidic and heterogeneous catalyst for green, simple and efficient synthesis of 6-amino-4-(4-methoxyphenyl)-5-cyano-3-methyl- 1-phenyl-1,4-dihydropyrano

Synthesis of pyrano[2,3-c]pyrazoles by ionic liquids under green and eco-safe conditions

Optimization of a green approach to the synthesis of pyrano[2,3-c]pyrazoles based on the one-pot, four-component condensation via a domino Knoevenagel/Michael/cyclization sequence was investigated. This method involved the evaluation of the activity of se

Sodium gluconate: An efficient organocatalyst for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives

Sodium gluconate presented as a category of biomolecule found to be a proficient and recyclable organocatalyst for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives via one-pot multicomponent reaction of aryl aldehyde, malononitrile, ethyl acetoac

An efficient and green protocol for the synthesis of dihydropyrano [2,3-c] pyrazoles in aqueous medium using thiamine hydrochloride as a catalyst

A green and expedient approach for the synthesis of dihydropyrano[2,3-c] pyrazoles via four-component reaction of ethyl acetoacetate, hydrazine hydrate, aromatic aldehydes and malononitrile at room temperature under ultrasound irradiation is described. Th

An expedient and eco-friendly approach for multicomponent synthesis of dihydropyrano[2,3-c]pyrazoles using nano-Al2O3/BF3/Fe3O4 as reusable catalyst

The pyranopyrazole derivatives have many biological activities. They were synthesized via a four-component coupling of aromatic aldehyde, malononitrile, ethyl acetoacetate and hydrazine hydrate. In this study, dihydropyrano[2,3-c]pyrazoles have been synth

Ce(III) immobilized on aminated poly(vinyl chloride): high-performance synergistic bifunctional acid–base catalyst for one-pot synthesis of 1,4-dihydropyrano[2,3-c]pyrazoles

A bifunctional acid–base catalyst of CeIII immobilized on ethylenediamine (EDA)-grafted poly(vinyl chloride) (PVC) has been prepared by a simple approach. First, PVC was treated with EDA to afford aminated poly(vinyl chloride) (PVC–EDA). Therea

Synergetic effects of naturally sourced metal oxides in organic synthesis: a greener approach for the synthesis of pyrano[2,3-c]pyrazoles and pyrazolyl-4H-chromenes

Abstract: A clean and more economic protocol for the synthesis of pyrano[2,3-c]pyrazoles and pyrazolyl-4H-chromenes has been carried out using bael fruit ash (BFA) as a non-conventional natural catalyst in aqueous condition at ambient temperature. The catalyst was obtained from renewable resources by simple thermal treatment to dry rind of Aegle marmelos (Bael) fruit and formation of its active phase was confirmed by AAS, DSC-TGA, XRD, FT-IR, and SEM techniques. The BFA catalyst was found to be a green, highly active, easily biodegradable, and recyclable without loss of activity after the fifth run. The methodology provides an alternative platform to the conventional catalyzed process. Graphical Abstract: [Figure not available: see fulltext.].

Sodium ascorbate as an expedient catalyst for green synthesis of polysubstituted 5-aminopyrazole-4-carbonitriles and 6-amino-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles

Sodium ascorbate (SA) was used as a safe catalyst for the synthesis of 5-aminopyrazole-4-carbonitriles from the one-pot three-component cyclocondensation (3-CC) of aldehydes, phenylhydrazine, and malononitrile at 50?°C. This 3-CC proceeds in a mixture of

One-pot four-component synthesis of 1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles catalyzed by potassium phthalimide

The potassium phthalimide (PPI) promoted a domino Knoevenagel-Michael-cyclocondensation of a wide variety of aldehydes, ethyl acetoacetate, malononitrile, and hydrazine derivatives to afford the 1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles in high yie