29681-45-6Relevant articles and documents
Preparation method of methanol solution of rupatadine fumarate intermediate methyl 5-methyl nicotinate
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Paragraph 0034-0037, (2021/08/06)
The invention relates to a preparation method of a methanol solution of rupatadine fumarate intermediate methyl 5-methyl nicotinate, which comprises the following steps of: 1, adding 5-methyl nicotinic acid into methanol, stirring for dissolving, adding thionyl chloride, and heating for reflux reaction; and 2, carrying out vacuum concentration to remove part of the solvent, adding a sodium methoxide methanol solution at room temperature, adjusting the pH value, and filtering to obtain a methanol solution of 5-methyl nicotinate.
Preparation process of Rupatadine
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Paragraph 0054; 0060; 0066; 0072; 0078; 0084; 0090; 0096, (2017/08/28)
The invention discloses a rupatadine preparation process, which comprises: S1, preparing methyl 5-methylnicotinate; S2, preparing 5-methyl-3-pyridinemethanol; S3, preparing 3-methyl-5-chloromethylpyridine hydrochloride; and S4, preparing rupatadine. According to the present invention, the preparation process has advantages of low cost, mild reaction condition, simple operation, low requirement onequipment, good product purity and high yield, and is suitable for large-scale industrial production.
An improved process for the preparation of Rupatadine Fumarate
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Paragraph 0039, (2015/02/02)
The present invention provides an improved process for the preparation of Rupatadine Fumarate of Formula-1 resulting product which is substantially free from di-alcohols, dimer and quaternary impurities.