297-76-7 Usage
Description
Ethynodiol diacetate is a synthetic progestogen. It prevents the development of osteoporosis in ovariectomized rats when administered at a dose of 9 μg/animal per day. Ethynodiol diacetate inhibits copulatory ovulation in rabbits. Formulations containing ethynodiol diacetate have been used as oral contraceptives.
Originator
Lutometrodiol,Searle,France,1965
Uses
Different sources of media describe the Uses of 297-76-7 differently. You can refer to the following data:
1. Ethynodiol Diacetate is used as a hormonal contraceptive, birth control.
2. anticonvulsant
Manufacturing Process
A mixture of 30 parts of 17α-ethynyl-19-norandrost-4-ene-3β,17β-diol, 360
parts of dry pyridine, and 111 parts of acetic anhydride, under nitrogen, is
stirred and heated at the reflux temperature for about 5 hours. This reaction
mixture is cooled, then poured into approximately 3,500 parts of cold water
and the resulting aqueous mixture is stirred at room temperature for about
0.5 hour. The precipitate which forms is collected by filtration, then is washed
on the filter with water and dried in air. This solid material is extracted into
ether, and the ether solution is washed successively with 10% aqueous
Therapeutic Function
Progestin; Oral contraceptive ingredient
General Description
Ethynodiol diacetate, 19-norpregn-4-en-20-yne-3β,17α-diol diacetate, is a prodrug ofnorethindrone. A combination of hydrolysis of both estersand oxidation of the C3 alcohol to the ketone is necessary toprovide the fully active progestin.
Safety Profile
Suspected carcinogen.
Human reproductive effects by ingestion:
menstrual cycle changes. Experimental
reproductive effects. Mutation data
reported. A steroid. When heated to decomposition it emits acrid smoke and
irritating fumes.
Check Digit Verification of cas no
The CAS Registry Mumber 297-76-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 2,9 and 7 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 297-76:
(5*2)+(4*9)+(3*7)+(2*7)+(1*6)=87
87 % 10 = 7
So 297-76-7 is a valid CAS Registry Number.
InChI:InChI=1/C24H32O4/c1-5-16-13-22-21-8-6-17-12-18(27-14(2)25)7-9-19(17)20(21)10-11-24(22,4)23(16)28-15(3)26/h1,12,16,18-23H,6-11,13H2,2-4H3/t16-,18+,19?,20?,21?,22?,23+,24+/m1/s1
