29712-30-9

Usage

Uses

Used in Pharmaceutical Industry:
[(dimethylamino)methylene]bisphosphonic acid is used as a therapeutic agent for the treatment of conditions such as osteoporosis, Paget's disease, and hypercalcemia. Its application is based on its ability to inhibit osteoclast activity, which helps prevent bone loss and increase bone density, providing long-term management for these conditions.
Used in Industrial Applications:
In the industrial sector, [(dimethylamino)methylene]bisphosphonic acid is used as a scale inhibitor in water systems. Its application is due to its ability to prevent the formation of scale, which can cause blockages and reduce the efficiency of water systems.

InChI:InChI=1/C3H11NO6P2.Tc/c1-4(2)3(11(5,6)7)12(8,9)10;/h3H,1-2H3,(H2,5,6,7)(H2,8,9,10);/q;+4/p-4/i;1+1

Upstream product

• 18855-52-2 tetraethyl dimethylaminomethylenediphosphonate 
• 68-12-2 N,N-dimethyl-formamide 
• 37909-50-5 Dimethylaminomethan-trisphosphonsaeurehexaethylester 
• 106753-26-8 tetra(trimethylsilyl) dimethylaminomethylenediphosphonate 

Downstream Products

• 18855-52-2 tetraethyl dimethylaminomethylenediphosphonate 

Relevant academic research and scientific papers

Synthesis of new types of aminomethylenediphosphorus-containing acids and their derivatives

Convenient methods for synthesis of various aminomethylenediphosphorus-containing acids and their derivatives starting from available trimethylsilyl esters of hypophosphorous and phosphorous acids, ethoxymethyleneimine hydrochlorides, and N-substituted formamides have been proposed. Selected properties of the obtained compounds have been examined.

Synthesis and reactivity of the new trimethylsilyl esters of aminomethylenebisorganophosphorus acids

The interaction of trimethylsilyl esters of trivalent organophosphorus acids containing PH and POSiMe3 fragments in the presence of trimethylsilyl trifluoromethanesulfonate as catalyst is proposed as a convenient method for the synthesis of new trimethylsilyl esters of aminomethylenebisorganophosphorus acids with three and four coordinated phosphorus. Also the new functionalized derivatives of the aminomethylenebisphosphinic acids with substituted hydroxymethyl moieties are synthesized, and some properties of the obtained compounds are presented.

Convenient synthesis of analogs of aminomethylene gem-diphosphonic acid from amines without catalyst

A simple, novel, and convenient synthesis of analogs of aminomethylene gem-diphosphonic acids in one-pot from primary and secondary amines in moderate yields was reported without catalyst.

Oral compositions

Oral compositions providing antitartar and antigingivitis benefits containing an antitartar agent and a stannous salt.

CRYSTALLINE DIMETHYLAMINOMETHANEDIPHOSPHONIC ACID: THE EXISTENCE OF ANHYDROUS AND MONOHYDRATE FORMS

There has been some discrepancy in the literature as to whether solid dimethylaminomethanediphosphonic acid existed as the anhydrous form or the monohydrate.We report the synthesis and characterization of both forms. 31P solid-state NMR data are given. - Key words: Aminophosphonates; NMR, solid; structure; dimethylaminomethanediphosphonic acid.

α-Substituted Phosphonates. 47. Splitting of P-C-Bonds from Trisphosphoryl Compounds

Hexaethyldimethylaminomethyl-trisphosphonate (2a) reacts with HCl or trimethylsilylbromid/water by splitting off one phosphoryl group, giving dimethylaminomethyl-bisphosphonic acid (7).The result of methylation of 2a depends on the reagent: with methyliodide one phosphoryl group is split off, and the ammonium salt 11a is formed, while with methyl toluene sulfonate or dimethylsulfate the expected quarternary ammonium salts 10b or 10c are formed.One phosphoryl group of 10c is split off under acidic as well as alkalinous conditions: acidic hydrolysis gives the bisphosphonic acid 15, while under alkalinous conditions the known ylid 16 is formed.

Process for preparing dimethylaminomethylenebis(phosphonic acid)

Dimethylaminomethylenebis(phosphonic acid) is prepared by reacting dimethylformamide with phosphorous trichloride and treating the reaction mixture with alcohols or glycols and water. The phosphonic acid is combined with water soluble carboxylic acid polymers for use as a corrosion and scale inhibitor in aqueous systems. These compositions may also be combined with phosphorous acid and water soluble zinc salts.

Oral composition for calculus retardation

Oral compositions, such as toothpaste, mouthwash, and the like, containing certain polyphosphonic acids and their salts which retard dental calculus formation without damaging tooth structure.