29713-96-0

Upstream product

• 60-18-4 L-tyrosine 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 5254-68-2 N-(N,O-bis-benzyloxycarbonyl-L-tyrosyl)-L-isoleucine methyl ester 
• 83549-85-3 1-(N,O-bis-benzyloxycarbonyl-L-tyrosyl)-L-proline-methyl ester 
• 64693-63-6 N,O-bis-benzyloxycarbonyl-L-tyrosyl chloride 
• 16789-90-5 N-(N,O-bis-benzyloxycarbonyl-L-tyrosyl)-L-tyrosine ethyl ester 
• 121177-11-5 N,O-bis-benzyloxycarbonyl-L-tyrosyl=>L-tyrosyl=>L-tyrosine ethyl ester 
• 51783-65-4 (S)-4-(4-benzyloxycarbonyloxy-benzyl)-oxazolidine-2,5-dione 
• 122389-68-8 N,O-bis-benzyloxycarbonyl-L-tyrosine cyanomethyl ester 
• 7641-11-4 -leucinmethylester 
• 15364-47-3 N,O-Dibenzyloxycarbonyl-Tyr-Ser-methylester 
• 57228-47-4 O,N-(Dicarbobenzoxy)-L-tyrosyl-aethylamid 
• 57228-38-3 N-Carbobenzoxy-L-tyrosyl-di-n-propylamid 
• 22840-22-8 N,O-Bis-benzyloxycarbonyl-Tyr-(N,N-dimethyl-hydrazid) 
• 57228-50-9 N,O-bis-benzyloxycarbonyl-L-tyrosine benzylamide 
• 100350-48-9 Z-Tyr(Z)-Gly-N₂H₂Boc 

Relevant academic research and scientific papers

Deprotection of t-butyl esters of amino acid derivatives by nitric acid in dichloromethane

The extension of the deprotection procedure of t-butylated carboxyl function using HNO3 in CH2Cl2 to a number of appropriately selected N-Z- derivatives of natural amino acid esters was investigated. The method was found to work effectively with alanine, phenylalanine, serine and the dipeptide aspartame, but the reagent brought about a number of unwanted transformations with tyrosine, methionine and tryptophan. Suitable protection of functions present in the latter ones allowed selective ester dealkylation, but tyrosine underwent unavoidable fast preliminary ring nitration. 2000 Elsevier Science Ltd.

Pharmaceutical composition having an excellent absorption property

A compound represented by the formula: STR1 wherein R1 is a hydrogen atom, a fluorine atom, a nitro group, a hydroxyl group or a hydroxyl group protected by an esterifying group; X is CO or SO2 ; --Y-- is a straight bond, a lower alkylene group, a substituted or unsubstituted vinylene group, or group having the formula --CH2 --O-- or --O--CH2 --; R2 is a substituted or unsubstituted phenyl or naphthyl group, or R2 --Y--CO is N-benzyloxycarbonylphenylalanyl, N-benzyloxycarbonyl-4-fluorophenylalanyl or N-(m-methoxycinnamoyl)-phenylalanyl group; or a non-toxic salt thereof is disclosed along with pharmaceutical compositions containing these compounds and methods of using these compositions to increase the rate of absorption of medicines.

O-Tertiary amino-alkyl-N-benzoyl tyrosil amides

Tyrosine derivatives of the formula: STR1 wherein: R1 is a linear or branched-chain alkyl group having 1-6 carbon atoms, terminating by a tertiary amino group; R 2 is an unsubstituted, monosubstituted or di-substituted phenyl or benzyloxy group, the substituent being --Cl, --Br, --NO2, --OCH3, --CH3 or --CF3 ; R3 is a primary, secondary or tertiary amino group or an aryl-alkylamino group having 7-9 carbon atoms; and salts of said tyrosine derivatives with pharmaceutically acceptable acids.